Literature DB >> 25494855

The association of the MTHFR c.1625A>C genetic variant with the risk of congenital heart diseases in the Chinese.

Yuting Wang1, Lei Sun, Weina Du, Shuang Song, Shuo Wang, Weiju Jiang, Tianchu Huang, Hui Li.   

Abstract

The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with the risk of congenital heart diseases (CHD). The genotypes of the MTHFR genetic variant were determined by the polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. Our data suggested that the allelic and genotypic frequencies of CHD patients were significantly different from non-CHD controls. The MTHFR c.1625A>C genetic variant was significantly associated with the increased risk of CHD (CC vs. AA: odds ratio [OR]=2.29, 95% confidence interval [CI] 1.15-4.53, p=0.016; C vs. A: OR=1.47, 95% CI 1.11-1.96, p=0.008). Results from this study indicate that the MTHFR c.1625A>C genetic variant influences the risk of CHD in the studied population.

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Year:  2015        PMID： 25494855      PMCID： PMC4278078          DOI： 10.1089/gtmb.2014.0253

Source DB:  PubMed          Journal:  Genet Test Mol Biomarkers        ISSN： 1945-0257


  23 in total

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Authors:  Mariska Klerk; Petra Verhoef; Robert Clarke; Henk J Blom; Frans J Kok; Evert G Schouten
Journal:  JAMA       Date:  2002 Oct 23-30       Impact factor: 56.272

2.  Polymorphism 677C → T MTHFR gene in Mexican mothers of children with complex congenital heart disease.

Authors:  Norma A Balderrábano-Saucedo; Rocio Sánchez-Urbina; José A Sierra-Ramírez; Normand García-Hernández; Adriana Sánchez-Boiso; Miguel Klunder-Klunder; Diego Arenas-Aranda; Gabriela Bravo-Hernández; Penelope Noriega-Zapata; Alfredo Vizcaíno-Alarcón
Journal:  Pediatr Cardiol       Date:  2012-06-04       Impact factor: 1.655

3.  Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus.

Authors:  Wenli L Zhu; Yong Li; Liying Yan; Jingjing Dao; Shuqin Li
Journal:  Mol Hum Reprod       Date:  2005-12-22       Impact factor: 4.025

4.  The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism.

Authors:  K Mehlig; K Leander; U de Faire; F Nyberg; C Berg; A Rosengren; L Björck; H Zetterberg; K Blennow; G Tognon; K Torén; E Strandhagen; L Lissner; D Thelle
Journal:  Heart       Date:  2013-09-07       Impact factor: 5.994

5.  Congenital heart disease in the general population: changing prevalence and age distribution.

Authors:  Ariane J Marelli; Andrew S Mackie; Raluca Ionescu-Ittu; Elham Rahme; Louise Pilote
Journal:  Circulation       Date:  2007-01-08       Impact factor: 29.690

6.  MTHFR polymorphisms in Puerto Rican children with isolated congenital heart disease and their mothers.

Authors:  Lourdes García-Fragoso; Inés García-García; Gloria Leavitt; Jessicca Renta; Miguel A Ayala; Carmen L Cadilla
Journal:  Int J Genet Mol Biol       Date:  2010-03-01

7.  Methylenetetrahydrofolate reductase 677 C-->T mutation and coronary heart disease risk in UK Indian Asians.

Authors:  J C Chambers; H Ireland; E Thompson; P Reilly; O A Obeid; H Refsum; P Ueland; D A Lane; J S Kooner
Journal:  Arterioscler Thromb Vasc Biol       Date:  2000-11       Impact factor: 8.311

8.  Meta analysis of the association between MTHFR C677T polymorphism and the risk of congenital heart defects.

Authors:  Meng Yin; Lingyan Dong; Jinghao Zheng; Haibo Zhang; Jinfen Liu; Zhiwei Xu
Journal:  Ann Hum Genet       Date:  2012-01       Impact factor: 1.670

9.  Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.

Authors:  Dingxu Gong; Haiyong Gu; YuJian Zhang; Jie Gong; Yu Nie; Jue Wang; Hui Zhang; Ruiping Liu; Shengshou Hu; Hao Zhang
Journal:  Clin Chem Lab Med       Date:  2012-02-04       Impact factor: 3.694

10.  Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls.

Authors:  Chrysovalanto Mamasoula; R Reid Prentice; Tomasz Pierscionek; Faith Pangilinan; James L Mills; Charlotte Druschel; Kenneth Pass; Mark W Russell; Darroch Hall; Ana Töpf; Danielle L Brown; Diana Zelenika; Jamie Bentham; Catherine Cosgrove; Shoumo Bhattacharya; Javier Granados Riveron; Kerry Setchfield; J David Brook; Frances A Bu'Lock; Chris Thornborough; Thahira J Rahman; Julian Palomino Doza; Huay L Tan; John O'Sullivan; A Graham Stuart; Gillian Blue; David Winlaw; Alex V Postma; Barbara J M Mulder; Aelko H Zwinderman; Klaartje van Engelen; Antoon F M Moorman; Anita Rauch; Marc Gewillig; Jeroen Breckpot; Koen Devriendt; G Mark Lathrop; Martin Farrall; Judith A Goodship; Heather J Cordell; Lawrence C Brody; Bernard D Keavney
Journal:  Circ Cardiovasc Genet       Date:  2013-07-22
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  1 in total

1.  Correlation between rs198388 and rs198389 polymorphismsin brainnatriuretic peptide (NPPB) gene and susceptibility to congenital heart diseases in a Chinese population.

Authors:  Qing Zhang; Fang-Qi Gong; Wei-Hua Zhu; Chun-Hong Xie; Yi-Ying Zhang; Li-Yang Ying
Journal:  Int J Clin Exp Med       Date:  2015-10-15
  1 in total

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