PURPOSE: To present and evaluate research criteria for the diagnosis of birdshot chorioretinopathy. DESIGN: Consensus statement. METHODS: Investigators who attended an international conference on birdshot chorioretinopathy drafted diagnostic criteria, which were refined after comment by conference attendees. Sensitivity and specificity of the criteria were evaluated by review of 82 previously diagnosed cases and evaluation of 80 consecutive patients with other forms of uveitis. RESULTS: Criteria, including presence of "birdshot lesions" and mild intraocular inflammation in both eyes, are based on clinical findings in the absence of systemic disease; HLA-A29 is supportive of diagnosis, but not required. Diagnostic criteria were found to be 100% specific and 97.5% sensitive. Positive predictive value was 100%; negative predictive value was 97.6%. CONCLUSIONS: Standardized criteria for the diagnosis of birdshot chorioretinopathy will facilitate clinical research and the comparison of results from studies performed at different institutions by ensuring a homogeneous population of study patients.
PURPOSE: To present and evaluate research criteria for the diagnosis of birdshot chorioretinopathy. DESIGN: Consensus statement. METHODS: Investigators who attended an international conference on birdshot chorioretinopathy drafted diagnostic criteria, which were refined after comment by conference attendees. Sensitivity and specificity of the criteria were evaluated by review of 82 previously diagnosed cases and evaluation of 80 consecutive patients with other forms of uveitis. RESULTS: Criteria, including presence of "birdshot lesions" and mild intraocular inflammation in both eyes, are based on clinical findings in the absence of systemic disease; HLA-A29 is supportive of diagnosis, but not required. Diagnostic criteria were found to be 100% specific and 97.5% sensitive. Positive predictive value was 100%; negative predictive value was 97.6%. CONCLUSIONS: Standardized criteria for the diagnosis of birdshot chorioretinopathy will facilitate clinical research and the comparison of results from studies performed at different institutions by ensuring a homogeneous population of study patients.
Authors: Jonas J W Kuiper; Jessica Van Setten; Stephan Ripke; Ruben Van 'T Slot; Flip Mulder; Tom Missotten; G Seerp Baarsma; Laurent C Francioli; Sara L Pulit; Carolien G F De Kovel; Ninette Ten Dam-Van Loon; Anneke I Den Hollander; Paulien Huis in het Veld; Carel B Hoyng; Miguel Cordero-Coma; Javier Martín; Victor Llorenç; Bharti Arya; Dhanes Thomas; Steven C Bakker; Roel A Ophoff; Aniki Rothova; Paul I W De Bakker; Tuna Mutis; Bobby P C Koeleman Journal: Hum Mol Genet Date: 2014-06-22 Impact factor: 6.150
Authors: Olga Garcia-Garcia; Sara Jordan-Cumplido; Olaia Subira-Gonzalez; Pere Garcia-Bru; Luis Arias; Josep M Caminal-Mitjana Journal: Graefes Arch Clin Exp Ophthalmol Date: 2017-05-03 Impact factor: 3.117