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Literature DB >> 16380168

Cytokine profile of iron-laden macrophages: implications for cellular magnetic resonance imaging.

Ines Siglienti¹, Martin Bendszus, Christoph Kleinschnitz, Guido Stoll.

Abstract

Superparamagnetic iron oxide (SPIO/USPIO) particles are a promising new tool to label cells for in vivo monitoring of their migration into the nervous system by magnetic resonance imaging (MRI). Upon systemic application, SPIO/USPIO particles are preferentially internalized by macrophages. It is unclear whether this affects their immunological profile. We tested the cytokine production of rat and mouse macrophages in vitro and found that internalization of SPIO/USPIO shifted macrophages towards an anti-inflammatory, less responsive phenotype by enhancing interleukin (IL)-10 and inhibiting tumor necrosis factor (TNF)-alpha production. During macrophage interaction with T-cells IL-12p40 secretion was inhibited. Based on our in vitro findings, potential immunomodulatory effects of SPIO/USPIO particles in vivo warrant further investigation.

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Year: 2005 PMID： 16380168 DOI： 10.1016/j.jneuroim.2005.11.011

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

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Cited

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Cytokine profile of iron-laden macrophages: implications for cellular magnetic resonance imaging.

1. Labeling and Imaging of Stem Cells - Promises and Concerns.

2. Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles.

Review 3. Advances in detection and characterization of atherosclerosis using contrast agents targeting the macrophage.

Review 4. Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational considerations.

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