Literature DB >> 16378375

Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta.

Diaa T A Youssef1, Lamiaa A Shaala, Samy Emara.   

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 7 (1), was isolated from the Red Sea sponge Hyrtios erecta, together with 16-epi-scalarolbutenolide (2), 25-dehydroxy-12-epi-deacetylscalarin (3), 3-acetylsesterstatin 1 (4), and 21-acetoxydeoxyscalarin. The structure of 1 was elucidated by spectroscopic data interpretation. Sesterstatin 7 (1) showed 63% inhibition of Mycobacterium tuberculosis (H(37)Rv) at a concentration of 6.25 microg/mL. Compound 2 displayed moderate inhibitory activity, while 3 and 4 were weakly active against the same biological target.

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Year:  2005        PMID： 16378375     DOI： 10.1021/np0502645

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Molecular architecture and biomedical leads of terpenes from red sea marine invertebrates.

Authors:  Mohamed Elamir F Hegazy; Tarik A Mohamed; Montaser A Alhammady; Alaa M Shaheen; Eman H Reda; Abdelsamed I Elshamy; Mina Aziz; Paul W Paré
Journal:  Mar Drugs       Date:  2015-05-20       Impact factor: 5.118

2.  Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus.

Authors:  Sameh S Elhady; Ahmed M Al-Abd; Ali M El-Halawany; Abdulrahman M Alahdal; Hashim A Hassanean; Safwat A Ahmed
Journal:  Mar Drugs       Date:  2016-07-08       Impact factor: 5.118

3.  Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease.

Authors:  Huda A Wahab; Ngoc B Pham; Tengku S Tengku Muhammad; John N A Hooper; Ronald J Quinn
Journal:  Mar Drugs       Date:  2016-12-27       Impact factor: 5.118

Review 4.  Bioactive Natural Products of Marine Sponges from the Genus Hyrtios.

Authors:  Nourhan Hisham Shady; Ebaa M El-Hossary; Mostafa A Fouad; Tobias A M Gulder; Mohamed Salah Kamel; Usama Ramadan Abdelmohsen
Journal:  Molecules       Date:  2017-05-11       Impact factor: 4.411

5.  Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldiasp.

Authors:  Bo-Rong Peng; Kuei-Hung Lai; You-Ying Chen; Jui-Hsin Su; Yusheng M Huang; Yu-Hsin Chen; Mei-Chin Lu; Steve Sheng-Fa Yu; Chang-Yih Duh; Ping-Jyun Sung
Journal:  Mar Drugs       Date:  2020-01-24       Impact factor: 5.118

6.  Bioactive compounds from the Red Sea marine sponge Hyrtios species.

Authors:  Diaa T A Youssef; Lamiaa A Shaala; Hani Z Asfour
Journal:  Mar Drugs       Date:  2013-03-28       Impact factor: 5.118

7.  Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus.

Authors:  Abdulrahman M Alahdal; Hani Z Asfour; Safwat A Ahmed; Ahmad O Noor; Ahmed M Al-Abd; Mahmoud A Elfaky; Sameh S Elhady
Journal:  Molecules       Date:  2018-04-23       Impact factor: 4.411

Review 8.  Natural Products Repertoire of the Red Sea.

Authors:  Ebaa M El-Hossary; Mohammad Abdel-Halim; Eslam S Ibrahim; Sheila Marie Pimentel-Elardo; Justin R Nodwell; Heba Handoussa; Miada F Abdelwahab; Ulrike Holzgrabe; Usama Ramadan Abdelmohsen
Journal:  Mar Drugs       Date:  2020-09-04       Impact factor: 5.118

9.  Molecular Docking and Dynamics Simulation Study of Hyrtios erectus Isolated Scalarane Sesterterpenes as Potential SARS-CoV-2 Dual Target Inhibitors.

Authors:  Sameh S Elhady; Reda F A Abdelhameed; Rania T Malatani; Abdulrahman M Alahdal; Hanin A Bogari; Ahmad J Almalki; Khadijah A Mohammad; Safwat A Ahmed; Amgad I M Khedr; Khaled M Darwish
Journal:  Biology (Basel)       Date:  2021-05-01
  9 in total

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