PURPOSE: To demonstrate the feasibility of hepatic catheterization for selective delivery of therapeutic agents using a clinical MRI scanner for real-time image guidance. MATERIALS AND METHODS: Experiments were performed in three domestic pigs (70-80 kg) using a clinical 1.5-T MR scanner. After abdominal three-dimensional contrast-enhanced MR angiography (3D-CE-MRA) was performed, endovascular devices with susceptibility markers were tracked with passive tracking techniques. Catheters were maneuvered into the primary and secondary hepatic arteries. Selective catheterization was verified using selective time-resolved CE angiography. Paramagnetic microspheres were administered to a different region for each liver. The resulting biodistributions were investigated using MR images. RESULTS: Successful selective hepatic catheterization was repeatedly demonstrated using passive tracking techniques. 3D-CE-MRA significantly aided the interventional procedure by showing the vascular anatomy, and maximum-intensity projections (MIPs) were used as roadmaps during the interventions. In all cases, microspheres were successfully delivered to the selected regions. The catheters were visualized at a maximum frame rate of five frames per second, allowing a good depiction of the devices and a reliable catheterization of the hepatic arteries. CONCLUSION: Fully MR-guided real-time navigation of endovascular devices permits complex procedures such as selective intra-arterial delivery of therapeutic agents to parts of the liver. (c) 2005 Wiley-Liss, Inc.
PURPOSE: To demonstrate the feasibility of hepatic catheterization for selective delivery of therapeutic agents using a clinical MRI scanner for real-time image guidance. MATERIALS AND METHODS: Experiments were performed in three domestic pigs (70-80 kg) using a clinical 1.5-T MR scanner. After abdominal three-dimensional contrast-enhanced MR angiography (3D-CE-MRA) was performed, endovascular devices with susceptibility markers were tracked with passive tracking techniques. Catheters were maneuvered into the primary and secondary hepatic arteries. Selective catheterization was verified using selective time-resolved CE angiography. Paramagnetic microspheres were administered to a different region for each liver. The resulting biodistributions were investigated using MR images. RESULTS: Successful selective hepatic catheterization was repeatedly demonstrated using passive tracking techniques. 3D-CE-MRA significantly aided the interventional procedure by showing the vascular anatomy, and maximum-intensity projections (MIPs) were used as roadmaps during the interventions. In all cases, microspheres were successfully delivered to the selected regions. The catheters were visualized at a maximum frame rate of five frames per second, allowing a good depiction of the devices and a reliable catheterization of the hepatic arteries. CONCLUSION: Fully MR-guided real-time navigation of endovascular devices permits complex procedures such as selective intra-arterial delivery of therapeutic agents to parts of the liver. (c) 2005 Wiley-Liss, Inc.
Authors: Gerrit H van de Maat; Peter R Seevinck; Mattijs Elschot; Maarten L J Smits; Hendrik de Leeuw; Alfred D van Het Schip; Maarten A D Vente; Bernard A Zonnenberg; Hugo W A M de Jong; Marnix G E H Lam; Max A Viergever; Maurice A A J van den Bosch; Johannes F W Nijsen; Chris J G Bakker Journal: Eur Radiol Date: 2012-09-27 Impact factor: 5.315
Authors: M A D Vente; T C de Wit; M A A J van den Bosch; W Bult; P R Seevinck; B A Zonnenberg; H W A M de Jong; G C Krijger; C J G Bakker; A D van het Schip; J F W Nijsen Journal: Eur Radiol Date: 2009-09-30 Impact factor: 5.315
Authors: M A D Vente; J F W Nijsen; T C de Wit; J H Seppenwoolde; G C Krijger; P R Seevinck; A Huisman; B A Zonnenberg; T S G A M van den Ingh; A D van het Schip Journal: Eur J Nucl Med Mol Imaging Date: 2008-03-11 Impact factor: 9.236
Authors: Remco Bastiaannet; S Cheenu Kappadath; Britt Kunnen; Arthur J A T Braat; Marnix G E H Lam; Hugo W A M de Jong Journal: EJNMMI Phys Date: 2018-11-02