| Literature DB >> 16372136 |
Jung-Min Koh1,2, Bermseok Oh3, Jong Yong Lee3, Jong-Keuk Lee3, Kuchan Kimm3, Ghi Su Kim1,2, Byung Lae Park4, Hyun Sub Cheong4, Hyoung Doo Shin4, Jung Min Hong1, Tae-Ho Kim1, Eui Kyun Park5, Shin-Yoon Kim1,6.
Abstract
Bone mineral density (BMD), the major factor determining bone strength, is closely related to osteoporotic fracture risk and is determined largely by multiple genetic factors. Semaphorin 7a (SEMA7A), a recently described member of the semaphorin family, has been shown to play a critical role in the activation of monocyte/macrophages that share progenitors with bone-resorbing osteoclasts and thus might contribute to osteoclast development. In the present study, we directly sequenced the SEMA7A gene in 24 Korean individuals, and identified 15 sequence variants. Five polymorphisms (+15667G > A, +15775C > G, +16285C > T, +19317C > T, +22331A > G) were selected and genotyped in postmenopausal Korean women (n = 560) together with measurement of the areal BMD (g/cm2) of the anterior-posterior lumbar spine and the non-dominant proximal femur using dual-energy X-ray absorptiometry. We found that polymorphisms of the SEMA7A gene were associated with the BMD of the lumbar spine and femoral neck. SEMA7A + 15775C > G and SEMA7A+22331A > G were associated with low BMD of the femoral neck (P = 0.02) and lumbar spine (P = 0.04) in a recessive model. SEMA7A-ht4 also showed an association with risk of vertebral fracture (OR = 1.87-1.93, P = 0.02-0.03). Our results suggest that variations in SEMA7A may play a role in decreased BMD and risk of vertebral fracture.Entities:
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Year: 2005 PMID： 16372136 DOI： 10.1007/s10038-005-0331-z
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172