OBJECTIVE: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. METHODS: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. RESULTS: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. INTERPRETATION: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.
OBJECTIVE:Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. METHODS: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. RESULTS: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. INTERPRETATION: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.
Authors: Katharina Eikermann-Haerter; Jeong Hyun Lee; Izumi Yuzawa; Christina H Liu; Zhipeng Zhou; Hwa Kyoung Shin; Yi Zheng; Tao Qin; Tobias Kurth; Christian Waeber; Michel D Ferrari; Arn M J M van den Maagdenberg; Michael A Moskowitz; Cenk Ayata Journal: Circulation Date: 2011-12-05 Impact factor: 29.690
Authors: Dale R Nyholt; K Steven LaForge; Mikko Kallela; Kirsi Alakurtti; Verneri Anttila; Markus Färkkilä; Eija Hämaläinen; Jaakko Kaprio; Mari A Kaunisto; Andrew C Heath; Grant W Montgomery; Hartmut Göbel; Unda Todt; Michel D Ferrari; Lenore J Launer; Rune R Frants; Gisela M Terwindt; Boukje de Vries; W M Monique Verschuren; Jan Brand; Tobias Freilinger; Volker Pfaffenrath; Andreas Straube; Dennis G Ballinger; Yiping Zhan; Mark J Daly; David R Cox; Martin Dichgans; Arn M J M van den Maagdenberg; Christian Kubisch; Nicholas G Martin; Maija Wessman; Leena Peltonen; Aarno Palotie Journal: Hum Mol Genet Date: 2008-08-02 Impact factor: 6.150
Authors: Miles C Benton; Rod A Lea; Donia Macartney-Coxson; Melanie A Carless; Harald H Göring; Claire Bellis; Michelle Hanna; David Eccles; Geoffrey K Chambers; Joanne E Curran; Jacquie L Harper; John Blangero; Lyn R Griffiths Journal: Am J Hum Genet Date: 2013-12-05 Impact factor: 11.025