BACKGROUND: Although a correlation between the central dopaminergic system and intelligence may exist, the results from imaging studies remain inconclusive. The aim of this study was to explore the relationship between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient (VIQ) using single photon emission computed tomography (SPECT). METHOD: Striatal D2/D3 receptor availability of 64 healthy subjects was determined with the [123I]iodobenzamide ([123I]IBZM) ligand. Intelligence quotients (IQs) of the subjects were measured by the Wechsler Adult Intelligence Scale--Revised (WAIS-R). RESULTS: In addition to age, left striatal D2/D3 receptor availability correlated positively with VIQ. In females, left striatal D2/D3 receptor availability was the only variable that correlated significantly with the similarities subtest of VIQ. CONCLUSIONS: There is a relationship between left striatal D2/D3 receptor availability and verbal intelligence, which varies, predominantly in males.
BACKGROUND: Although a correlation between the central dopaminergic system and intelligence may exist, the results from imaging studies remain inconclusive. The aim of this study was to explore the relationship between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient (VIQ) using single photon emission computed tomography (SPECT). METHOD: Striatal D2/D3 receptor availability of 64 healthy subjects was determined with the [123I]iodobenzamide ([123I]IBZM) ligand. Intelligence quotients (IQs) of the subjects were measured by the Wechsler Adult Intelligence Scale--Revised (WAIS-R). RESULTS: In addition to age, left striatal D2/D3 receptor availability correlated positively with VIQ. In females, left striatal D2/D3 receptor availability was the only variable that correlated significantly with the similarities subtest of VIQ. CONCLUSIONS: There is a relationship between left striatal D2/D3 receptor availability and verbal intelligence, which varies, predominantly in males.
Authors: Rachael G Grazioplene; Sephira G Ryman; Jeremy R Gray; Aldo Rustichini; Rex E Jung; Colin G DeYoung Journal: Hum Brain Mapp Date: 2014-12-09 Impact factor: 5.038
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Authors: Pei Chun Hsieh; Tzung Lieh Yeh; I Hui Lee; Hui Chun Huang; Po See Chen; Yen Kuang Yang; Nan Tsing Chiu; Ru Band Lu; Mei-Hsiu Liao Journal: J Psychiatry Neurosci Date: 2010-03 Impact factor: 6.186
Authors: Sarah A Eisenstein; Danuta M Gredysa; Jo Ann Antenor-Dorsey; Leonard Green; Ana Maria Arbeláez; Jonathan M Koller; Kevin J Black; Joel S Perlmutter; Stephen M Moerlein; Tamara Hershey Journal: PLoS One Date: 2015-07-20 Impact factor: 3.240