Literature DB >> 1635068

1-(5'-Fluoro-6'-hydroxy-5',6'-dihydrouracil-5'-yl)-5-fluorouracil, a novel N(1)-C(5)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic conditions.

S Nishimoto1, H Hatta, H Ueshima, T Kagiya.   

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Year:  1992        PMID： 1635068     DOI： 10.1021/jm00092a023

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  4 in total

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2.  White light-mediated Cu (II)-5FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study.

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3.  A novel class of antitumor prodrug, 1-(2'-oxopropyl)-5-fluorouracil (OFU001), that releases 5-fluorouracil upon hypoxic irradiation.

Authors:  Y Shibamoto; L Zhou; H Hatta; M Mori; S Nishimoto
Journal:  Jpn J Cancer Res       Date:  2000-04

Review 4.  Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors.

Authors:  Takeo Ito; Kazuhito Tanabe; Hisatsugu Yamada; Hiroshi Hatta; Sei-ichi Nishimoto
Journal:  Molecules       Date:  2008-10-01       Impact factor: 4.411
  4 in total

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