Literature DB >> 16349003

Glutamate Dehydrogenase Is Not Essential for Glutamate Formation by Corynebacterium glutamicum.

E R Kholy1, B J Eikmanns, M Gutmann, H Sahm.   

Abstract

Two Corynebacterium glutamicum strains, one being glutamate dehydrogenase (GDH) negative and the other possessing 11-fold-higher specific GDH activity than the parental wild type, were constructed and used to analyze the role of GDH in C. glutamicum. The results indicate (i) that GDH is dispensable for glutamate synthesis required for growth and (ii) that although a high level of GDH increases the intracellular glutamate pool, the level of GDH has no influence on glutamate secretion.

Entities:  

Year:  1993        PMID： 16349003      PMCID： PMC182279          DOI： 10.1128/aem.59.7.2329-2331.1993

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  10 in total

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4.  Molecular analysis of the Corynebacterium glutamicum gdh gene encoding glutamate dehydrogenase.

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5.  Enzymes of the glutamate and aspartate synthetic pathways in a glutamate-producing bacterium, Brevibacterium flavum.

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6.  Some properties of glutamate dehydrogenase, glutamine synthetase and glutamate synthase from Corynebacterium callunae.

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7.  A family of Corynebacterium glutamicum/Escherichia coli shuttle vectors for cloning, controlled gene expression, and promoter probing.

Authors:  B J Eikmanns; E Kleinertz; W Liebl; H Sahm
Journal:  Gene       Date:  1991-06-15       Impact factor: 3.688

8.  Effect of biotin on the bacterial formation of glutamic acid. I. Glutamate formation and cellular premeability of amino acids.

Authors:  I SHIIO; S I OTSUKA; M TAKAHASHI
Journal:  J Biochem       Date:  1962-01       Impact factor: 3.387

9.  Amplification of three threonine biosynthesis genes in Corynebacterium glutamicum and its influence on carbon flux in different strains.

Authors:  B J Eikmanns; M Metzger; D Reinscheid; M Kircher; H Sahm
Journal:  Appl Microbiol Biotechnol       Date:  1991-02       Impact factor: 4.813

10.  Manipulation of Corynebacterium glutamicum by gene disruption and replacement.

Authors:  A Schwarzer; A Pühler
Journal:  Biotechnology (N Y)       Date:  1991-01
  10 in total
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4.  Glutamate Biosynthesis in Lactococcus lactis subsp. lactis NCDO 2118

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Journal:  Appl Environ Microbiol       Date:  1998-07-01       Impact factor: 4.792

5.  The NADP-glutamate dehydrogenase of the cyanobacterium Synechocystis 6803: cloning, transcriptional analysis and disruption of the gdhA gene.

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7.  Modular control of multiple pathways of Corynebacterium glutamicum for 5-aminolevulinic acid production.

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  7 in total

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