Literature DB >> 16345540

Production of Eremofortins A, B, and C Relative to Formation of PR Toxin by Penicillium roqueforti.

S Moreau1, A Lablache-Combier, J Biguet.   

Abstract

The production of various eremophilane-type sesquiterpenes by Penicillium roqueforti strains has allowed us to propose a biochemical pathway for PR toxin synthesis. A time-course study of P. roqueforti metabolite production by high-performance liquid chromatography was performed to check this hypothetical pathway. The results obtained suggested that eremofortin C was the direct precursor of PR toxin in the P. roqueforti cell. Attempts to determine the amount of PR toxin in the mycelium failed. It was shown that the absence of PR toxin in mycelium was due to its instability during the extraction procedure.

Entities:  

Year:  1980        PMID： 16345540      PMCID： PMC291417          DOI： 10.1128/aem.39.4.770-776.1980

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  5 in total

1.  In vitro metabolism of penicillium roqueforti toxin (PRT) and a structurally related compound, eremofortin A, by rat liver.

Authors:  M Cacan; S Moreau; R Tailliez
Journal:  Toxicology       Date:  1977-10       Impact factor: 4.221

2.  Eremofortin C.A new metabolite obtained from penicillium roqueforti cultures and from biotransformation of PR toxin.

Authors:  S Moreau; M Cacan
Journal:  J Org Chem       Date:  1977-07-22       Impact factor: 4.354

3.  Relationships between the chemical structure and the biological properties of some eremophilane compounds related to PR toxin.

Authors:  Y Moulé; S Moreau; J F Bousquet
Journal:  Chem Biol Interact       Date:  1977-05       Impact factor: 5.192

4.  Instability of PR toxin in blue cheese.

Authors:  P M Scott; S R Kanhere
Journal:  J Assoc Off Anal Chem       Date:  1979-01

5.  Study of conditions of production of roquefortine and other metabolites of Penicillin roqueforti.

Authors:  P M Scott; B P Kennedy; J Harwig; B J Blanchfield
Journal:  Appl Environ Microbiol       Date:  1977-02       Impact factor: 4.792
  5 in total
  8 in total

1.  Isolation and Some Properties of the Enzyme That Transforms Eremofortin C to PR Toxin.

Authors:  S C Chang; Y H Wei; M L Liu; R D Wei
Journal:  Appl Environ Microbiol       Date:  1985-06       Impact factor: 4.792

Review 2.  Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways.

Authors:  Juan F Martín
Journal:  J Ind Microbiol Biotechnol       Date:  2016-08-26       Impact factor: 3.346

3.  Isolation, purification, and characterization of the PR oxidase from penicillium roqueforti

Authors: 
Journal:  Appl Environ Microbiol       Date:  1998-12       Impact factor: 4.792

4.  Factors affecting the production of eremofortin C and PR toxin in Penicillium roqueforti.

Authors:  S C Chang; Y H Wei; D L Wei; Y Y Chen; S C Jong
Journal:  Appl Environ Microbiol       Date:  1991-09       Impact factor: 4.792

5.  Production of ochratoxin a, citrinin, and ergosterol byPenicillium viridicatum in autoclaved and non-autoclaved wheat at low temperature.

Authors:  A Boley; H M Müller
Journal:  Mycotoxin Res       Date:  1986-09       Impact factor: 3.833

6.  Secondary metabolites resulting from degradation of PR toxin by Penicillium roqueforti.

Authors:  S C Chang; K L Lu; S F Yeh
Journal:  Appl Environ Microbiol       Date:  1993-04       Impact factor: 4.792

7.  Chemical transformation of eremofortin C into PR toxin.

Authors:  S Y Li; S C Chang; R D Wei
Journal:  Appl Environ Microbiol       Date:  1985-09       Impact factor: 4.792

Review 8.  PR Toxin - Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges.

Authors:  Manish K Dubey; Mohd Aamir; Manish S Kaushik; Saumya Khare; Mukesh Meena; Surendra Singh; Ram S Upadhyay
Journal:  Front Pharmacol       Date:  2018-03-29       Impact factor: 5.810
  8 in total

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