RATIONALE: It is well established that humans and rats respond to an imperative stimulus more rapidly as a function of the foreperiod preceding the target, and with this decrease in mean response time, there is also an increase in anticipatory (prior to the signal) responses. These changes reflect enhanced motor readiness. Also, reaction times are quicker when the cost of reward (amount of work required) is minimum. Antagonism of the adenosine A(2A) receptor has been shown to effect motor-related processes. OBJECTIVE: This study examined the behavioural effects of systemic administration of the adenosine A(2A) antagonist KW-6002 in a cued reaction time task in the rat. The purpose of this study is to ascertain whether KW-6002 would enhance motor readiness and effect performance as a function of reward cost. METHODS: Rats were trained on a visually cued reaction time task with variable foreperiods, and the effects of three doses of KW-6002 (0.3, 1.0 and 3.0 mg/kg systemically, compared to vehicle) were examined. RESULTS: Increasing doses of KW-6002 resulted in faster reaction times and an increase in the number of anticipatory responses. KW-6002 enhanced the foreperiod effect on reaction time distributions and anticipatory responses. In addition, KW-6002 had differential effects on performance between rewarded and unrewarded trials. CONCLUSION: Antagonism of adenosine A(2A) receptors by systemic KW-6002 speeds reaction time and enhanced motor preparatory processes as well as interacting with motivational processes.
RATIONALE: It is well established that humans and rats respond to an imperative stimulus more rapidly as a function of the foreperiod preceding the target, and with this decrease in mean response time, there is also an increase in anticipatory (prior to the signal) responses. These changes reflect enhanced motor readiness. Also, reaction times are quicker when the cost of reward (amount of work required) is minimum. Antagonism of the adenosine A(2A) receptor has been shown to effect motor-related processes. OBJECTIVE: This study examined the behavioural effects of systemic administration of the adenosine A(2A) antagonist KW-6002 in a cued reaction time task in the rat. The purpose of this study is to ascertain whether KW-6002 would enhance motor readiness and effect performance as a function of reward cost. METHODS:Rats were trained on a visually cued reaction time task with variable foreperiods, and the effects of three doses of KW-6002 (0.3, 1.0 and 3.0 mg/kg systemically, compared to vehicle) were examined. RESULTS: Increasing doses of KW-6002 resulted in faster reaction times and an increase in the number of anticipatory responses. KW-6002 enhanced the foreperiod effect on reaction time distributions and anticipatory responses. In addition, KW-6002 had differential effects on performance between rewarded and unrewarded trials. CONCLUSION: Antagonism of adenosine A(2A) receptors by systemic KW-6002 speeds reaction time and enhanced motor preparatory processes as well as interacting with motivational processes.
Authors: John D Salamone; Andrew M Farrar; Laura Font; Vatsal Patel; Devra E Schlar; Eric J Nunes; Lyndsey E Collins; Thomas N Sager Journal: Behav Brain Res Date: 2009-03-03 Impact factor: 3.332
Authors: Lila T Worden; Mona Shahriari; Andrew M Farrar; Kelly S Sink; Jörg Hockemeyer; Christa E Müller; John D Salamone Journal: Psychopharmacology (Berl) Date: 2008-12-02 Impact factor: 4.530
Authors: Patrick A Randall; Eric J Nunes; Simone L Janniere; Colin M Stopper; Andrew M Farrar; Thomas N Sager; Younis Baqi; Jörg Hockemeyer; Christa E Müller; John D Salamone Journal: Psychopharmacology (Berl) Date: 2011-02-24 Impact factor: 4.530
Authors: Andrew M Farrar; Mariana Pereira; Francisco Velasco; Jörg Hockemeyer; Christa E Müller; John D Salamone Journal: Psychopharmacology (Berl) Date: 2006-10-27 Impact factor: 4.530
Authors: Susana Mingote; Mariana Pereira; Andrew M Farrar; Peter J McLaughlin; John D Salamone Journal: Pharmacol Biochem Behav Date: 2008-01-17 Impact factor: 3.533
Authors: Laura Font; Susana Mingote; Andrew M Farrar; Mariana Pereira; Lila Worden; Colin Stopper; Russell G Port; John D Salamone Journal: Psychopharmacology (Berl) Date: 2008-05-20 Impact factor: 4.530
Authors: Allison M Mott; Eric J Nunes; Lyndsey E Collins; Russell G Port; Kelly S Sink; Jörg Hockemeyer; Christa E Müller; John D Salamone Journal: Psychopharmacology (Berl) Date: 2009-01-09 Impact factor: 4.530