Literature DB >> 16343459

Fast oxidation of thioglycosides to glycosyl sulfones using KMnO4/CuSO4*5H2O under neutral reaction conditions.

Geetanjali Agnihotri1, Anup Kumar Misra.   

Abstract

A rapid oxidation of thioglycosides to glycosyl sulfones has been achieved using a combination of KMnO4 and CuSO4*5H2O in acetonitrile and water. This reaction protocol has many advantages compared to other methods available for this transformation, including compatibility with acid and base labile functional groups used for the protection of carbohydrates, high yields, fast reaction times, and moderate reaction temperatures. The yields obtained were excellent in all cases.

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Year:  2005        PMID: 16343459     DOI: 10.1016/j.carres.2005.11.025

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN: 0008-6215            Impact factor:   2.104


  1 in total

1.  Urea-hydrogen peroxide prompted the selective and controlled oxidation of thioglycosides into sulfoxides and sulfones.

Authors:  Adesh Kumar Singh; Varsha Tiwari; Kunj Bihari Mishra; Surabhi Gupta; Jeyakumar Kandasamy
Journal:  Beilstein J Org Chem       Date:  2017-06-13       Impact factor: 2.883

  1 in total

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