| Literature DB >> 16338068 |
Jun Wang1, Kaichun Wu, Feihu Bai, Huihong Zhai, Huahong Xie, Yulei Du, Jie Liang, Shuang Han, Yu Chen, Tao Lin, Daiming Fan.
Abstract
We investigated the potential effect of Cyclooxygenase-2 (Cox-2) on hypoxia-induced Angiopoietin-2 (Ang-2) expression in gastric cancer cells. Our results revealed that hypoxia augmented Cox-2 and Ang-2 expressions. Also, the hypoxia-induced Ang-2 could be mimicked by CoCl(2) treatment while genestein treatment could partially counteract the hypoxia-induced Ang-2 expression. Celecoxib but not Cox-1 inhibitor sc-560 reversed the hypoxia-induced Ang-2 expression, while this effect could be partially restored by addition of exogenous PGE2. Our findings suggest that the hypoxia-elevated Ang-2 expression in gastric cancer cells may be mediated by both Cox-2-derived PGE2 and HIF-1alpha pathways, while celecoxib could counteract the hypoxia-induced Ang-2 expression.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16338068 DOI： 10.1016/j.canlet.2005.10.030
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679