AIM: The aim of the study was to evaluate the prognostic significance of tumour-infiltrating lymphocytes (TILs) in local prostate cancer (PC). MATERIALS AND METHODS: TILs were counted and routine histological variables were assessed from radical prostatectomy specimens in 188 cases of PC. Immunohistochemical (IHC) characterisation of the lymphocytes was done by using CD4 and CD8 antibodies for detection of T lymphocytes and CD20 antibody for B lymphocytes in tissue microarray construction. The results of the lymphocyte analyses were compared to other prognostic factors and PSA recurrence-free survival (RFS). RESULTS: Strong expression of TILs, CD4, CD8 and CD20 lymphocytes were seen in 28%, 33%, 35% and 15% of the cases, respectively. CD4 and CD8, as well as CD4 and CD20, lymphocytes were correlated to each other (p < 0.0001), but not to clinical or histopathological parameters. Weak expression of TILs was correlated with intracapsular carcinoma (p = 0.004), while perineural invasion (p = 0.017) and capsular invasion (p < 0.0001) were related to strong expression of TILs. Shortened PSA RFS was associated with strong expression of TILs (p = 0.005). In Cox regression analysis, independent predictors of shortened PSA RFS were strong expression of TILs (p = 0.012) and high Gleason score (p < 0.001). CONCLUSION: TILs are an independent predictor of short PSA RFS in patients with local PC treated by radical prostatectomy.
AIM: The aim of the study was to evaluate the prognostic significance of tumour-infiltrating lymphocytes (TILs) in local prostate cancer (PC). MATERIALS AND METHODS: TILs were counted and routine histological variables were assessed from radical prostatectomy specimens in 188 cases of PC. Immunohistochemical (IHC) characterisation of the lymphocytes was done by using CD4 and CD8 antibodies for detection of T lymphocytes and CD20 antibody for B lymphocytes in tissue microarray construction. The results of the lymphocyte analyses were compared to other prognostic factors and PSA recurrence-free survival (RFS). RESULTS: Strong expression of TILs, CD4, CD8 and CD20 lymphocytes were seen in 28%, 33%, 35% and 15% of the cases, respectively. CD4 and CD8, as well as CD4 and CD20, lymphocytes were correlated to each other (p < 0.0001), but not to clinical or histopathological parameters. Weak expression of TILs was correlated with intracapsular carcinoma (p = 0.004), while perineural invasion (p = 0.017) and capsular invasion (p < 0.0001) were related to strong expression of TILs. Shortened PSA RFS was associated with strong expression of TILs (p = 0.005). In Cox regression analysis, independent predictors of shortened PSA RFS were strong expression of TILs (p = 0.012) and high Gleason score (p < 0.001). CONCLUSION: TILs are an independent predictor of short PSA RFS in patients with local PC treated by radical prostatectomy.
Authors: Shona Hendry; Roberto Salgado; Thomas Gevaert; Prudence A Russell; Tom John; Bibhusal Thapa; Michael Christie; Koen van de Vijver; M V Estrada; Paula I Gonzalez-Ericsson; Melinda Sanders; Benjamin Solomon; Cinzia Solinas; Gert G G M Van den Eynden; Yves Allory; Matthias Preusser; Johannes Hainfellner; Giancarlo Pruneri; Andrea Vingiani; Sandra Demaria; Fraser Symmans; Paolo Nuciforo; Laura Comerma; E A Thompson; Sunil Lakhani; Seong-Rim Kim; Stuart Schnitt; Cecile Colpaert; Christos Sotiriou; Stefan J Scherer; Michail Ignatiadis; Sunil Badve; Robert H Pierce; Giuseppe Viale; Nicolas Sirtaine; Frederique Penault-Llorca; Tomohagu Sugie; Susan Fineberg; Soonmyung Paik; Ashok Srinivasan; Andrea Richardson; Yihong Wang; Ewa Chmielik; Jane Brock; Douglas B Johnson; Justin Balko; Stephan Wienert; Veerle Bossuyt; Stefan Michiels; Nils Ternes; Nicole Burchardi; Stephen J Luen; Peter Savas; Frederick Klauschen; Peter H Watson; Brad H Nelson; Carmen Criscitiello; Sandra O'Toole; Denis Larsimont; Roland de Wind; Giuseppe Curigliano; Fabrice André; Magali Lacroix-Triki; Mark van de Vijver; Federico Rojo; Giuseppe Floris; Shahinaz Bedri; Joseph Sparano; David Rimm; Torsten Nielsen; Zuzana Kos; Stephen Hewitt; Baljit Singh; Gelareh Farshid; Sibylle Loibl; Kimberly H Allison; Nadine Tung; Sylvia Adams; Karen Willard-Gallo; Hugo M Horlings; Leena Gandhi; Andre Moreira; Fred Hirsch; Maria V Dieci; Maria Urbanowicz; Iva Brcic; Konstanty Korski; Fabien Gaire; Hartmut Koeppen; Amy Lo; Jennifer Giltnane; Marlon C Rebelatto; Keith E Steele; Jiping Zha; Kenneth Emancipator; Jonathan W Juco; Carsten Denkert; Jorge Reis-Filho; Sherene Loi; Stephen B Fox Journal: Adv Anat Pathol Date: 2017-11 Impact factor: 3.875
Authors: Lisa K Spary; Josephine Salimu; Jason P Webber; Aled Clayton; Malcolm D Mason; Zsuzsanna Tabi Journal: Oncoimmunology Date: 2014-12-13 Impact factor: 8.110
Authors: Christina Hägglöf; Peter Hammarsten; Andreas Josefsson; Pär Stattin; Janna Paulsson; Anders Bergh; Arne Ostman Journal: PLoS One Date: 2010-05-20 Impact factor: 3.240