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Literature DB >> 16333108

Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center.

Russell E Lewis¹, Nathan P Wiederhold, Michail S Lionakis, Randall A Prince, Dimitrios P Kontoyiannis.

Abstract

Aspergillus isolates (n = 103) collected from cancer patients were screened to determine the taxonomic distribution and quantity of gliotoxin production. Gliotoxin was detected in 93% of Aspergillus fumigatus, 75% of A. niger, 25% of A. terreus, and 4% of A. flavus cultures. Gliotoxin concentrations were highest in cultures of A. fumigatus.

Entities: Disease Species

Mesh：

Substances：
Culture Media
Gliotoxin

Year: 2005 PMID： 16333108 PMCID： PMC1317213 DOI： 10.1128/JCM.43.12.6120-6122.2005

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

14 in total

Review 1. The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis.

Authors: Donald M Gardiner; Paul Waring; Barbara J Howlett
Journal: Microbiology Date: 2005-04 Impact factor: 2.777

Review 2. The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines.

Authors: P Waring; R D Eichner; A Müllbacher
Journal: Med Res Rev Date: 1988 Oct-Dec Impact factor: 12.944

3. Suppressive effects of Aspergillus fumigatus culture filtrates on human alveolar macrophages and polymorphonuclear leucocytes.

Authors: T Murayama; R Amitani; Y Ikegami; R Nawada; W J Lee; F Kuze
Journal: Eur Respir J Date: 1996-02 Impact factor: 16.671

4. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus.

Authors: S Ascioglu; J H Rex; B de Pauw; J E Bennett; J Bille; F Crokaert; D W Denning; J P Donnelly; J E Edwards; Z Erjavec; D Fiere; O Lortholary; J Maertens; J F Meis; T F Patterson; J Ritter; D Selleslag; P M Shah; D A Stevens; T J Walsh
Journal: Clin Infect Dis Date: 2001-11-26 Impact factor: 9.079

5. Colorimetric assay for antifungal susceptibility testing of Aspergillus species.

Authors: J Meletiadis; J W Mouton; J F Meis; B A Bouman; J P Donnelly; P E Verweij
Journal: J Clin Microbiol Date: 2001-09 Impact factor: 5.948

Review 6. Putative virulence factors of Aspergillus fumigatus.

Authors: J F Tomee; H F Kauffman
Journal: Clin Exp Allergy Date: 2000-04 Impact factor: 5.018

Review 7. The pathobiology of Aspergillus fumigatus.

Authors: J P Latgé
Journal: Trends Microbiol Date: 2001-08 Impact factor: 17.079

8. Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro.

Authors: A Müllbacher; P Waring; R D Eichner
Journal: J Gen Microbiol Date: 1985-05

9. In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi.

Authors: P Sutton; N R Newcombe; P Waring; A Müllbacher
Journal: Infect Immun Date: 1994-04 Impact factor: 3.441

10. The effect of gliotoxin upon macrophage function.

Authors: R D Eichner; M Al Salami; P R Wood; A Müllbacher
Journal: Int J Immunopharmacol Date: 1986

34 in total

1. Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.

Authors: Robert A Cramer; Michael P Gamcsik; Rhea M Brooking; Laura K Najvar; William R Kirkpatrick; Thomas F Patterson; Carl J Balibar; John R Graybill; John R Perfect; Soman N Abraham; William J Steinbach
Journal: Eukaryot Cell Date: 2006-06

2. Assessment of multi-contaminant exposure in a cancer treatment center: a 2-year monitoring of molds, mycotoxins, endotoxins, and glucans in bioaerosols.

Authors: Natacha Heutte; Véronique André; Catherine Dubos Arvis; Valérie Bouchart; Françoise Lemarié; Patrick Legendre; Edwige Votier; Marie-Yolande Louis; Stéphane Madelaine; Virginie Séguin; Stéphanie Gente; Philippe Vérité; David Garon
Journal: Environ Monit Assess Date: 2016-12-23 Impact factor: 2.513

Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center.

Review 1. The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis.

Review 2. The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines.

3. Suppressive effects of Aspergillus fumigatus culture filtrates on human alveolar macrophages and polymorphonuclear leucocytes.

4. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus.

5. Colorimetric assay for antifungal susceptibility testing of Aspergillus species.

Review 6. Putative virulence factors of Aspergillus fumigatus.

Review 7. The pathobiology of Aspergillus fumigatus.

8. Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro.

9. In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi.

10. The effect of gliotoxin upon macrophage function.

1. Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.

2. Assessment of multi-contaminant exposure in a cancer treatment center: a 2-year monitoring of molds, mycotoxins, endotoxins, and glucans in bioaerosols.

3. Galleria mellonella as a host model to study Aspergillus terreus virulence and amphotericin B resistance.

4. GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence.

5. Accessing indoor fungal contamination using conventional and molecular methods in Portuguese poultries.

6. A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans.

7. Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites.

8. Genomewide screening for genes associated with gliotoxin resistance and sensitivity in Saccharomyces cerevisiae.

Review 9. What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?

10. Gliotoxin penetrates and impairs the integrity of the human blood-brain barrier in vitro.