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Literature DB >> 16332900

An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin.

Kenneth C Ehrlich¹, Beverly Montalbano, Stephen M Boué, Deepak Bhatnagar.

Abstract

Disruption of the aflatoxin biosynthesis cluster gene aflY (hypA) gave Aspergillus parasiticus transformants that accumulated versicolorin A. This gene is predicted to encode the Baeyer-Villiger oxidase necessary for formation of the xanthone ring of the aflatoxin precursor demethylsterigmatocystin.

Entities: Chemical Species

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Year: 2005 PMID： 16332900 PMCID： PMC1317430 DOI： 10.1128/AEM.71.12.8963-8965.2005

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

22 in total

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Journal: Appl Environ Microbiol Date: 1992-11 Impact factor: 4.792

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Journal: Appl Environ Microbiol Date: 1994-05 Impact factor: 4.792

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Journal: J Biol Chem Date: 1995-09-15 Impact factor: 5.157

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Authors: N P Keller; S Segner; D Bhatnagar; T H Adams
Journal: Appl Environ Microbiol Date: 1995-10 Impact factor: 4.792

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4. Natural products version 2.0: connecting genes to molecules.

Authors: Christopher T Walsh; Michael A Fischbach
Journal: J Am Chem Soc Date: 2010-03-03 Impact factor: 15.419

5. The aflatoxin biosynthesis cluster gene, aflX, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin.

Authors: Jeffrey W Cary; Kenneth C Ehrlich; John M Bland; Beverly G Montalbano
Journal: Appl Environ Microbiol Date: 2006-02 Impact factor: 4.792

6. New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1.

Authors: David Conradt; Michael A Schätzle; Julian Haas; Craig A Townsend; Michael Müller
Journal: J Am Chem Soc Date: 2015-08-19 Impact factor: 15.419

7. Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway .

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Journal: Biochemistry Date: 2009-06-02 Impact factor: 3.162

8. Functional expression and subcellular localization of the aflatoxin pathway enzyme Ver-1 fused to enhanced green fluorescent protein.

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Review 9. Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update.

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Review 10. Predicted roles of the uncharacterized clustered genes in aflatoxin biosynthesis.

Authors: Kenneth C Ehrlich
Journal: Toxins (Basel) Date: 2009-09-25 Impact factor: 4.546