| Literature DB >> 16332350 |
Koichiro Uto1, Kazuya Yamamoto1, Shohei Hirase1, Takao Aoyagi2.
Abstract
The objective of this study is to develop a sensitive temperature-responsive material that would function near body temperature. To achieve this purpose, we compounded 2-branched and 4-branched poly(epsilon-caprolactone) macromonomers to modulate the transition temperatures of the resulting cross-linked materials. The temperature-responsive properties were studied using differential scanning calorimetry and X-ray diffraction measurements. As a result, the mixing ratios of each macromonomer or the total macromonomer concentrations were very dominant in modulating the transition temperatures. The materials could successfully control the permeation of the model drug, prednisolone, near body temperature.Entities:
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Year: 2005 PMID： 16332350 DOI： 10.1016/j.jconrel.2005.10.024
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776