UNLABELLED: Neurotransmission imaging studies require normative data for the statistical assessment of neurophysiologic dysfunctions. 2'-Methoxyphenyl-(N-2'-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine (18F-MPPF) is a specific serotonin 5-HT1A antagonist PET tracer recently characterized, modeled, and used for clinical research to explore abnormalities in the serotoninergic system. Our study reports, to our knowledge, the first large normative imaging database of 18F-MPPF binding potential (BP) over aging, for both males and females. METHODS: Fifty-three healthy volunteers (27 females, 26 males; age, 20-70 y) were selected to undergo structural MRI and single-injection 18F-MPPF multiframe dynamic PET. 18F-MPPF BP values were computed using a nonlinear modeling method with tissue reference. The statistical assessment of the effect of age and sex was performed both at the anatomic structure level, using regions of interest drawn manually on individual MR images, and at the voxel level, using normalized BP parametric images in different statistical parametric mapping designs. RESULTS: A negative linear correlation between age and 18F-MPPF binding (3.6% decrease by decade) was found in females but not in males and involved most of the limbic and paralimbic regions; on the other hand, males in their 30s showed decreased binding in most cerebral regions. CONCLUSION: A comparison of males and females revealed higher BP values independent of age in females in the right hemisphere and a different evolution of BP over aging. These results confirm the necessity of a database for further statistical analysis in individuals or groups with pathology.
UNLABELLED: Neurotransmission imaging studies require normative data for the statistical assessment of neurophysiologic dysfunctions. 2'-Methoxyphenyl-(N-2'-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine (18F-MPPF) is a specific serotonin5-HT1A antagonist PET tracer recently characterized, modeled, and used for clinical research to explore abnormalities in the serotoninergic system. Our study reports, to our knowledge, the first large normative imaging database of 18F-MPPF binding potential (BP) over aging, for both males and females. METHODS: Fifty-three healthy volunteers (27 females, 26 males; age, 20-70 y) were selected to undergo structural MRI and single-injection 18F-MPPF multiframe dynamic PET. 18F-MPPFBP values were computed using a nonlinear modeling method with tissue reference. The statistical assessment of the effect of age and sex was performed both at the anatomic structure level, using regions of interest drawn manually on individual MR images, and at the voxel level, using normalized BP parametric images in different statistical parametric mapping designs. RESULTS: A negative linear correlation between age and 18F-MPPF binding (3.6% decrease by decade) was found in females but not in males and involved most of the limbic and paralimbic regions; on the other hand, males in their 30s showed decreased binding in most cerebral regions. CONCLUSION: A comparison of males and females revealed higher BP values independent of age in females in the right hemisphere and a different evolution of BP over aging. These results confirm the necessity of a database for further statistical analysis in individuals or groups with pathology.
Authors: Goran Laćan; Alain Plenevaux; Daniel J Rubins; Baldwin M Way; Caroline Defraiteur; Christian Lemaire; Joel Aerts; André Luxen; Simon R Cherry; William P Melega Journal: Eur J Nucl Med Mol Imaging Date: 2008-07-05 Impact factor: 9.236
Authors: Beverly H Brummett; Stephen H Boyle; Cynthia M Kuhn; Ilene C Siegler; Redford B Williams Journal: Biol Psychol Date: 2008-03-12 Impact factor: 3.251
Authors: Beverly H Brummett; Christopher L Muller; Ann L Collins; Stephen H Boyle; Cynthia M Kuhn; Ilene C Siegler; Redford B Williams; Allison Ashley-Koch Journal: Behav Genet Date: 2008-07-26 Impact factor: 2.805
Authors: Daniel S Albrecht; Patrick D Skosnik; Jennifer M Vollmer; Margaret S Brumbaugh; Kevin M Perry; Bruce H Mock; Qi-Huang Zheng; Lauren A Federici; Elizabeth A Patton; Christine M Herring; Karmen K Yoder Journal: Drug Alcohol Depend Date: 2012-08-19 Impact factor: 4.492
Authors: Beverly H Brummett; Stephen H Boyle; Ilene C Siegler; Cynthia M Kuhn; Allison Ashley-Koch; Charles R Jonassaint; Stephan Züchner; Ann Collins; Redford B Williams Journal: Behav Genet Date: 2007-10-23 Impact factor: 2.805