| Literature DB >> 1632943 |
J Hyttel1, K P Bøgesø, J Perregaard, C Sánchez.
Abstract
The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers*) with the 1-(S) absolute configuration. In the 5-HT uptake test eudismic ratios of 167 and 6.6 are obtained for the enantiomers of citalopram and N-demethylcitalopram, respectively. The pharmacological profile of the eutomers of citalopram and N-demethylcitalopram very much resembles the profile of the respective racemates.Entities:
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Year: 1992 PMID： 1632943 DOI： 10.1007/bf01244820
Source DB: PubMed Journal: J Neural Transm Gen Sect