PURPOSE: Vitamin D deficiency leads to secondary hyperparathyroidism and osteomalacia, and both conditions are associated with fractures, the most severe being hip fracture. The serum 25-hydroxyvitamin D level depends on latitude and season. Yekaterinburg is situated at a high latitude and the duration of winter is about 5 months. METHODS: In this study, the serum 25(OH)D and PTH concentrations, and the prevalence of hypovitaminosis D in elderly people, inhabitants of Yekaterinburg, were investigated. The study was performed on 63 people with hip fracture (mean age, 68.8 years) and 97 independently living elderly people (mean age, 70.2 years). RESULTS: Serum 25(OH)D (mean+/-SD) in the hip fracture group was 22.4+/-11.4 nmol/L, significantly lower than in control group, which was 28.1+/-10.1 nmol/L. The percentage of patients with severe hypovitaminosis D (<25 nmol/L) in the hip fracture group was 65%, compared to 47% in the control group (p<0.05). The prevalence of hypovitaminosis D among hip fracture patients, as well as among independently living elderly people in Yekaterinburg, was high. CONCLUSION: Supplementation of vitamin D in elderly people with and without fracture might prevent secondary hyperparathyroidism, osteomalacia and fractures.
PURPOSE:Vitamin D deficiency leads to secondary hyperparathyroidism and osteomalacia, and both conditions are associated with fractures, the most severe being hip fracture. The serum 25-hydroxyvitamin D level depends on latitude and season. Yekaterinburg is situated at a high latitude and the duration of winter is about 5 months. METHODS: In this study, the serum 25(OH)D and PTH concentrations, and the prevalence of hypovitaminosis D in elderly people, inhabitants of Yekaterinburg, were investigated. The study was performed on 63 people with hip fracture (mean age, 68.8 years) and 97 independently living elderly people (mean age, 70.2 years). RESULTS: Serum 25(OH)D (mean+/-SD) in the hip fracture group was 22.4+/-11.4 nmol/L, significantly lower than in control group, which was 28.1+/-10.1 nmol/L. The percentage of patients with severe hypovitaminosis D (<25 nmol/L) in the hip fracture group was 65%, compared to 47% in the control group (p<0.05). The prevalence of hypovitaminosis D among hip fracturepatients, as well as among independently living elderly people in Yekaterinburg, was high. CONCLUSION: Supplementation of vitamin D in elderly people with and without fracture might prevent secondary hyperparathyroidism, osteomalacia and fractures.
Authors: Heike A Bischoff-Ferrari; Thomas Dietrich; E John Orav; Frank B Hu; Yuqing Zhang; Elisabeth W Karlson; Bess Dawson-Hughes Journal: Am J Clin Nutr Date: 2004-09 Impact factor: 7.045
Authors: S Boonen; D Vanderschueren; X G Cheng; G Verbeke; J Dequeker; P Geusens; P Broos; R Bouillon Journal: J Bone Miner Res Date: 1997-12 Impact factor: 6.741
Authors: G D Carter; C R Carter; E Gunter; J Jones; G Jones; H L J Makin; S Sufi Journal: J Steroid Biochem Mol Biol Date: 2004-05 Impact factor: 4.292
Authors: Nirali S Desai; Nestani Tukvadze; Jennifer K Frediani; Maia Kipiani; Ekaterine Sanikidze; Memorie M Nichols; Gautam Hebbar; Russell R Kempker; Veriko Mirtskhulava; Iagor Kalandadze; Shabnam Seydafkan; Nilay Sutaria; Tai C Chen; Henry M Blumberg; Thomas R Ziegler; Vin Tangpricha Journal: Nutrition Date: 2012-02-02 Impact factor: 4.008
Authors: Pang Yao; Ling Lu; Yao Hu; Gang Liu; Xiafei Chen; Liang Sun; Xingwang Ye; He Zheng; Yan Chen; Frank B Hu; Huaixing Li; Xu Lin Journal: Eur J Nutr Date: 2015-02-19 Impact factor: 5.614
Authors: S Maier; E Sidelnikov; B Dawson-Hughes; A Egli; R Theiler; A Platz; H B Staehelin; H-P Simmen; C Meier; W Dick; D Grob; A von Eckardstein; H A Bischoff-Ferrari Journal: Osteoporos Int Date: 2013-05-29 Impact factor: 4.507