Literature DB >> 1632499

Ion-exchange high-performance liquid chromatography analysis of oligodeoxyribonucleotide phosphorothioates.

V Metelev1, S Agrawal.   

Abstract

Oligodeoxynucleotide-containing phosphorothioate backbones have been used to regulate viral as well as cellular gene expression. The studies carried out in tissue culture have shown promising results on the use of oligonucleotide phosphorothioates as antiviral agents and, at present, study is underway to develop these oligonucleotide analogues as chemotherapeutic agents. To analyze and purify oligonucleotide analogues, high-performance liquid chromatography using weak anion exchange column has been described. The separation of oligonucleotide phosphorothioate is found to be length dependent.

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Year:  1992        PMID： 1632499     DOI： 10.1016/0003-2697(92)90476-n

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  7 in total

1.  Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA--in vitro and in vivo studies.

Authors:  Y Liao; Z Y Tang; K D Liu; S L Ye; Z Huang
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

2.  Antimalarial activities of oligodeoxynucleotide phosphorothioates in chloroquine-resistant Plasmodium falciparum.

Authors:  E Rapaport; K Misiura; S Agrawal; P Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

3.  Antimycobacterial activities of antisense oligodeoxynucleotide phosphorothioates in drug-resistant strains.

Authors:  E Rapaport; A Levina; V Metelev; P C Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-23       Impact factor: 11.205

Review 4.  Principles and methods for the analysis and purification of synthetic deoxyribonucleotides by high-performance liquid chromatography.

Authors:  W J Warren; G Vella
Journal:  Mol Biotechnol       Date:  1995-10       Impact factor: 2.695

5.  Inhibition of Plasmodium falciparum malaria using antisense oligodeoxynucleotides.

Authors:  R H Barker; V Metelev; E Rapaport; P Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

6.  Cationic PMMA nanoparticles bind and deliver antisense oligoribonucleotides allowing restoration of dystrophin expression in the mdx mouse.

Authors:  Paola Rimessi; Patrizia Sabatelli; Marina Fabris; Paola Braghetta; Elena Bassi; Pietro Spitali; Gaetano Vattemi; Giuliano Tomelleri; Lara Mari; Daniela Perrone; Alessandro Medici; Marcella Neri; Matteo Bovolenta; Elena Martoni; Nadir M Maraldi; Francesca Gualandi; Luciano Merlini; Marco Ballestri; Luisa Tondelli; Katia Sparnacci; Paolo Bonaldo; Antonella Caputo; Michele Laus; Alessandra Ferlini
Journal:  Mol Ther       Date:  2009-02-24       Impact factor: 11.454

Review 7.  The Evolution of Antisense Oligonucleotide Chemistry-A Personal Journey.

Authors:  Sudhir Agrawal
Journal:  Biomedicines       Date:  2021-05-03
  7 in total

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