BACKGROUND AND PURPOSE: Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke. METHODS: We compared the serum 25-dihydroxyvitamin D levels of 44 patients admitted to an acute stroke unit with first-ever stroke with results obtained by measuring 96 healthy ambulant elderly subjects every 2 months for 1 year. Statistical Z scores of serum vitamin D were then calculated after seasonal adjustment for the month of sampling. RESULTS: The mean Z score of vitamin D in acute stroke was -1.4 SD units (95% CI, -1.7, -1.1), with 77% of patients falling in the insufficient range. CONCLUSIONS: Reduced vitamin D was identified in the majority of patients with acute stroke throughout the year and may have preceded stroke. Vitamin D is a potential risk marker for stroke, and the role of vitamin D repletion in enhancing musculoskeletal health after stroke needs to be explored.
BACKGROUND AND PURPOSE:Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke. METHODS: We compared the serum 25-dihydroxyvitamin D levels of 44 patients admitted to an acute stroke unit with first-ever stroke with results obtained by measuring 96 healthy ambulant elderly subjects every 2 months for 1 year. Statistical Z scores of serum vitamin D were then calculated after seasonal adjustment for the month of sampling. RESULTS: The mean Z score of vitamin D in acute stroke was -1.4 SD units (95% CI, -1.7, -1.1), with 77% of patients falling in the insufficient range. CONCLUSIONS: Reduced vitamin D was identified in the majority of patients with acute stroke throughout the year and may have preceded stroke. Vitamin D is a potential risk marker for stroke, and the role of vitamin D repletion in enhancing musculoskeletal health after stroke needs to be explored.
Authors: E M Brouwer-Brolsma; H A Bischoff-Ferrari; R Bouillon; E J M Feskens; C J Gallagher; E Hypponen; D J Llewellyn; E Stoecklin; J Dierkes; A K Kies; F J Kok; C Lamberg-Allardt; U Moser; S Pilz; W H Saris; N M van Schoor; P Weber; R Witkamp; A Zittermann; L C P G M de Groot Journal: Osteoporos Int Date: 2012-12-11 Impact factor: 4.507
Authors: Erin D Michos; Elizabeth A Streeten; Kathleen A Ryan; Evadnie Rampersaud; Patricia A Peyser; Lawrence F Bielak; Alan R Shuldiner; Braxton D Mitchell; Wendy Post Journal: Calcif Tissue Int Date: 2009-01-16 Impact factor: 4.333
Authors: Lorella Polidoro; G Properzi; F Marampon; G L Gravina; C Festuccia; E Di Cesare; L Scarsella; C Ciccarelli; B M Zani; C Ferri Journal: J Cardiovasc Transl Res Date: 2012-12-18 Impact factor: 4.132
Authors: Kenneth E S Poole; Shobna Vedi; Irene Debiram; Collette Rose; Jon Power; Nigel Loveridge; Elizabeth A Warburton; Jonathan Reeve; Juliet Compston Journal: Bone Date: 2008-12-11 Impact factor: 4.398