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Literature DB >> 16322467

The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth.

Nathalie Kertesz¹, Valery Krasnoperov, Ramachandra Reddy, Lucy Leshanski, S Ram Kumar, Sergey Zozulya, Parkash S Gill.

Abstract

The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis. The soluble monomeric derivative of the extracellular domain of EphB4 (sEphB4) was designed as an antagonist of EphB4/EphrinB2 signaling. sEphB4 blocks activation of EphB4 and EphrinB2; suppresses endothelial cell migration, adhesion, and tube formation in vitro; and inhibits the angiogenic effects of various growth factors (VEGF and bFGF) in vivo. sEphB4 also inhibits tumor growth in murine tumor xenograft models. sEphB4 is thus a therapeutic candidate for vascular proliferative diseases and cancer.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16322467 PMCID： PMC1895726 DOI： 10.1182/blood-2005-04-1655

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

45 in total

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Authors: G Mellitzer; Q Xu; D G Wilkinson
Journal: Nature Date: 1999-07-01 Impact factor: 49.962

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Authors: J Frisén; J Holmberg; M Barbacid
Journal: EMBO J Date: 1999-10-01 Impact factor: 11.598

Review 3. Growth factor signaling pathways in vascular development.

Authors: M D Tallquist; P Soriano; R A Klinghoffer
Journal: Oncogene Date: 1999-12-20 Impact factor: 9.867

4. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.

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Journal: Neuron Date: 1999-03 Impact factor: 17.173

Review 5. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.

Authors: N W Gale; G D Yancopoulos
Journal: Genes Dev Date: 1999-05-01 Impact factor: 11.361

Review 6. EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis.

Authors: Hellmut G Augustin; Yvonne Reiss
Journal: Cell Tissue Res Date: 2003-08-02 Impact factor: 5.249

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Journal: Neuron Date: 1998-12 Impact factor: 17.173

8. EphB4 expression and biological significance in prostate cancer.

Authors: Guangbin Xia; S Ram Kumar; Rizwan Masood; Sutao Zhu; Ramchandra Reddy; Valery Krasnoperov; David I Quinn; Susan M Henshall; Robert L Sutherland; Jacek K Pinski; Siamak Daneshmand; Maurizio Buscarini; John P Stein; Chen Zhong; Daniel Broek; Pradip Roy-Burman; Parkash S Gill
Journal: Cancer Res Date: 2005-06-01 Impact factor: 12.701

9. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.

Authors: S S Gerety; H U Wang; Z F Chen; D J Anderson
Journal: Mol Cell Date: 1999-09 Impact factor: 17.970

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Authors: R H Adams; G A Wilkinson; C Weiss; F Diella; N W Gale; U Deutsch; W Risau; R Klein
Journal: Genes Dev Date: 1999-02-01 Impact factor: 11.361

60 in total

1. Notch4 normalization reduces blood vessel size in arteriovenous malformations.

Authors: Patrick A Murphy; Tyson N Kim; Gloria Lu; Andrew W Bollen; Chris B Schaffer; Rong A Wang
Journal: Sci Transl Med Date: 2012-01-18 Impact factor: 17.956

Review 2. Axon guidance molecules in vascular patterning.

Authors: Ralf H Adams; Anne Eichmann
Journal: Cold Spring Harb Perspect Biol Date: 2010-03-31 Impact factor: 10.005

Review 3. Eph receptors and ephrins in cancer: bidirectional signalling and beyond.

Authors: Elena B Pasquale
Journal: Nat Rev Cancer Date: 2010-03 Impact factor: 60.716

Review 4. Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis.

Authors: Ombretta Salvucci; Giovanna Tosato
Journal: Adv Cancer Res Date: 2012 Impact factor: 6.242

Review 5. Therapeutic targeting of EPH receptors and their ligands.

Authors: Andrew W Boyd; Perry F Bartlett; Martin Lackmann
Journal: Nat Rev Drug Discov Date: 2014-01 Impact factor: 84.694

6. Scutellarin suppresses human colorectal cancer metastasis and angiogenesis by targeting ephrinb2.

Authors: Ping Ting Zhu; Ming Mao; Zhao Guo Liu; Li Tao; Bing Chun Yan
Journal: Am J Transl Res Date: 2017-11-15 Impact factor: 4.060

7. Lentivirus vector-mediated knockdown of erythropoietin-producing hepatocellular carcinoma receptors B4 inhibits laser-induced choroidal neovascularization.

Authors: Jing Du; Wei Zhao; Yusheng Wang; Yan Cai
Journal: J Ocul Pharmacol Ther Date: 2012-10-04 Impact factor: 2.671