| Literature DB >> 16321510 |
Jadwiga Tritt-Goc1, Joanna Kowalczuk.
Abstract
Magnetic resonance microscopy was used to study the interaction of an alkaline water solvent (pH=12) with hydroxypropylmethyl cellulose (HPMC) matrices with different molecular masses Mw=12,000, 86,000, and 120,000. The polymers in the form of cylinders were hydrated at 37 degrees C and monitored at equal time intervals with a 300MHz Bruker AVANCE. The spatially resolved spin-spin relaxations times T2 and diffusion coefficients D of the solvent molecules within the gel layer of HPMC samples, along with changes in the dimension of the glass core of the polymers were determined as a function of hydration times. The experimental data allows us to characterize the diffusion mechanism as being Fickian and to determine the mean diffusivity values D of the solvent molecules for each voxel within the gel of the studied polymers. The influence of the molecular mass of the HPMC polymers on swelling properties has been shown.Entities:
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Year: 2005 PMID： 16321510 DOI： 10.1016/j.ssnmr.2005.10.012
Source DB: PubMed Journal: Solid State Nucl Magn Reson ISSN： 0926-2040 Impact factor: 2.293