| Literature DB >> 16321013 |
Daisuke Kato1, Steven H L Verhelst, Kelly B Sexton, Matthew Bogyo.
Abstract
[chemical reaction: see text]. A solid phase approach is presented for the synthesis of azapeptide inhibitors and activity based probes (ABPs) for cysteine proteases. This synthetic method allows the incorporation of diverse reactive warheads linked to different peptide recognition elements. Application of this method to the synthesis of a series of caspase probes is described.Entities:
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Year: 2005 PMID： 16321013 DOI： 10.1021/ol052275v
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005