Literature DB >> 16321010

Concise synthesis of pochonin A, an HSP90 inhibitor.

Emilie Moulin1, Sofia Barluenga, Nicolas Winssinger.   

Abstract

[chemical reaction: see text]. An expedient synthesis of (-)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.

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Year:  2005        PMID： 16321010     DOI： 10.1021/ol052263+

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

Review 1.  Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?

Authors:  Anuj Khandelwal; Vincent M Crowley; Brian S J Blagg
Journal:  Med Res Rev       Date:  2015-05-25       Impact factor: 12.944

Review 2.  Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides.

Authors:  Jing Xu; Cheng-shi Jiang; Zai-long Zhang; Wen-quan Ma; Yue-wei Guo
Journal:  Acta Pharmacol Sin       Date:  2014-01-27       Impact factor: 6.150

Review 3.  Natural product inhibitors of Hsp90: potential leads for drug discovery.

Authors:  M W Amolins; B S J Blagg
Journal:  Mini Rev Med Chem       Date:  2009-02       Impact factor: 3.862

Review 4.  Discovery and development of heat shock protein 90 inhibitors.

Authors:  Tony Taldone; Weilin Sun; Gabriela Chiosis
Journal:  Bioorg Med Chem       Date:  2008-11-06       Impact factor: 3.641

Review 5.  Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90.

Authors:  Kyu-Yeon Jun; Youngjoo Kwon
Journal:  Biomol Ther (Seoul)       Date:  2016-09-01       Impact factor: 4.634

6.  Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.

Authors:  Luke Whitesell; Nicole Robbins; David S Huang; Catherine A McLellan; Tanvi Shekhar-Guturja; Emmanuelle V LeBlanc; Catherine S Nation; Raymond Hui; Ashley Hutchinson; Cathy Collins; Sharanya Chatterjee; Richard Trilles; Jinglin L Xie; Damian J Krysan; Susan Lindquist; John A Porco; Utpal Tatu; Lauren E Brown; Juan Pizarro; Leah E Cowen
Journal:  Nat Commun       Date:  2019-01-24       Impact factor: 14.919
  6 in total

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