Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Testing and estimation in flexible group sequential designs with adaptive treatment selection.

Literature DB >> 16320264

Testing and estimation in flexible group sequential designs with adaptive treatment selection.

Martin Posch¹, Franz Koenig, Michael Branson, Werner Brannath, Cornelia Dunger-Baldauf, Peter Bauer.

Abstract

Integrating selection and confirmation phases into a single trial can expedite the development of new treatments and allows to use all accumulated data in the decision process. In this paper we review adaptive treatment selection based on combination tests and propose overall adjusted p-values and simultaneous confidence intervals. Also point estimation in adaptive trials is considered. The methodology is illustrated in a detailed example based on an actual planned study. Copyright 2005 John Wiley & Sons, Ltd.

Mesh：

Year: 2005 PMID： 16320264 DOI： 10.1002/sim.2389

Source DB: PubMed Journal: Stat Med ISSN： 0277-6715 Impact factor: 2.373

Keyword Cloud
Cited

36 in total

1. The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.

Authors: Munyaradzi Dimairo; Philip Pallmann; James Wason; Susan Todd; Thomas Jaki; Steven A Julious; Adrian P Mander; Christopher J Weir; Franz Koenig; Marc K Walton; Jon P Nicholl; Elizabeth Coates; Katie Biggs; Toshimitsu Hamasaki; Michael A Proschan; John A Scott; Yuki Ando; Daniel Hind; Douglas G Altman
Journal: BMJ Date: 2020-06-17

10. The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.

Testing and estimation in flexible group sequential designs with adaptive treatment selection.

1. The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.

2. Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment.

3. Response adaptive randomization procedures in seamless phase II/III clinical trials.

4. Twenty-five years of confirmatory adaptive designs: opportunities and pitfalls.

5. Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.

6. Confidence intervals for the selected population in randomized trials that adapt the population enrolled.

7. Two-stage designs for Phase 2 dose-finding trials.

8. Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

9. Simultaneous confidence intervals that are compatible with closed testing in adaptive designs.

10. The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.