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Literature DB >> 16311599

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.

Qizhi Tang¹, Jason Y Adams, Aaron J Tooley, Mingying Bi, Brian T Fife, Pau Serra, Pere Santamaria, Richard M Locksley, Matthew F Krummel, Jeffrey A Bluestone.

Abstract

The in vivo mechanism of regulatory T cell (T(reg) cell) function in controlling autoimmunity remains controversial. Here we have used two-photon laser-scanning microscopy to analyze lymph node priming of diabetogenic T cells and to delineate the mechanisms of T(reg) cell control of autoimmunity in vivo. Islet antigen-specific CD4(+)CD25(-) T helper cells (T(H) cells) and T(reg) cells swarmed and arrested in the presence of autoantigens. These T(H) cell activities were progressively inhibited in the presence of increasing numbers of T(reg) cells. There were no detectable stable associations between T(reg) and T(H) cells during active suppression. In contrast, T(reg) cells directly interacted with dendritic cells bearing islet antigen. Such persistent T(reg) cell-dendritic cell contacts preceded the inhibition of T(H) cell activation by dendritic cells, supporting the idea that dendritic cells are central to T(reg) cell function in vivo.

Entities: Disease Gene Species

Mesh：

Year: 2005 PMID： 16311599 PMCID： PMC3057888 DOI： 10.1038/ni1289

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

40 in total

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2. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential.

Authors: M Gunzer; A Schäfer; S Borgmann; S Grabbe; K S Zänker; E B Bröcker; E Kämpgen; P Friedl
Journal: Immunity Date: 2000-09 Impact factor: 31.745

Review 3. Suppressor T cells--they're back and critical for regulation of autoimmunity!

Authors: L Chatenoud; B Salomon; J A Bluestone
Journal: Immunol Rev Date: 2001-08 Impact factor: 12.988

Review 4. Control of intestinal inflammation by regulatory T cells.

Authors: B Singh; S Read; C Asseman; V Malmström; C Mottet; L A Stephens; R Stepankova; H Tlaskalova; F Powrie
Journal: Immunol Rev Date: 2001-08 Impact factor: 12.988

5. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

Authors: B Salomon; D J Lenschow; L Rhee; N Ashourian; B Singh; A Sharpe; J A Bluestone
Journal: Immunity Date: 2000-04 Impact factor: 31.745

6. T cell fitness determined by signal strength.

Authors: Amanda V Gett; Federica Sallusto; Antonio Lanzavecchia; Jens Geginat
Journal: Nat Immunol Date: 2003-03-17 Impact factor: 25.606

7. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood.

Authors: D Dieckmann; H Plottner; S Berchtold; T Berger; G Schuler
Journal: J Exp Med Date: 2001-06-04 Impact factor: 14.307

8. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood.

Authors: H Jonuleit; E Schmitt; M Stassen; A Tuettenberg; J Knop; A H Enk
Journal: J Exp Med Date: 2001-06-04 Impact factor: 14.307

9. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.

Authors: S Read; V Malmström; F Powrie
Journal: J Exp Med Date: 2000-07-17 Impact factor: 14.307

10. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

Authors: M K Levings; R Sangregorio; M G Roncarolo
Journal: J Exp Med Date: 2001-06-04 Impact factor: 14.307

322 in total

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Authors: Shoshana D Katzman; William E O'Gorman; Alejandro V Villarino; Eugenio Gallo; Rachel S Friedman; Matthew F Krummel; Garry P Nolan; Abul K Abbas
Journal: Proc Natl Acad Sci U S A Date: 2010-10-04 Impact factor: 11.205

Review 2. The immunological synapse.

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Journal: Cancer Immunol Res Date: 2014-11 Impact factor: 11.151

Review 3. Molecular and functional heterogeneity of T regulatory cells.

Authors: Lequn Li; Vassiliki A Boussiotis
Journal: Clin Immunol Date: 2011-08-30 Impact factor: 3.969

4. Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome.

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Journal: J Mol Cell Biol Date: 2012-07-06 Impact factor: 6.216