| Literature DB >> 16310892 |
Changsheng Wang1, Glenn T Stebbins, David L Nyenhuis, Leyla deToledo-Morrell, Sally Freels, Eugenia Gencheva, Laura Pedelty, Kumar Sripathirathan, Michael E Moseley, David A Turner, John D E Gabrieli, Philip B Gorelick.
Abstract
Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1-3 years following ischemic stroke. In a sample of 80 ischemic stroke patients, we obtained diffusion tensor imaging (DTI) measures of fractional anisotropy (FA), an apparent measure of white matter integrity, in radiologically normal-appearing white matter at baseline and 3 years of follow-up. Mixed model regression analysis results showed a significant improvement in FA from baseline during the first 2 years of follow-up that stabilized by the third year of follow-up. These results demonstrate a long-term improvement in apparent white matter integrity following ischemic stroke that continues, at least, into the second year following the insult.Entities:
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Year: 2005 PMID： 16310892 DOI： 10.1016/j.neurobiolaging.2005.10.008
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673