Literature DB >> 1631087

Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate.

H Matsue1, K G Rothberg, A Takashima, B A Kamen, R G Anderson, S W Lacey.   

Abstract

The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these cells are grown in physiological concentrations of folate, the receptor increases the efficiency of vitamin uptake by 30-fold. We now show that PAM 212 cells, a mouse keratinocyte cell line, are unable to grow in 1 nM 5-methyltetrahydrofolate unless they express a functional folate receptor. These results suggest that under certain conditions, tissue cells in the body may depend on the folate receptor to obtain enough 5-methyltetrahydrofolate for growth.

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Year:  1992        PMID： 1631087      PMCID： PMC402127          DOI： 10.1073/pnas.89.13.6006

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

1.  Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol.

Authors:  S W Lacey; J M Sanders; K G Rothberg; R G Anderson; B A Kamen
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

2.  Caveolin, a protein component of caveolae membrane coats.

Authors:  K G Rothberg; J E Heuser; W C Donzell; Y S Ying; J R Glenney; R G Anderson
Journal:  Cell       Date:  1992-02-21       Impact factor: 41.582

3.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

4.  Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles.

Authors:  B A Kamen; M T Wang; A J Streckfuss; X Peryea; R G Anderson
Journal:  J Biol Chem       Date:  1988-09-25       Impact factor: 5.157

5.  Regulation of the cytoplasmic accumulation of 5-methyltetrahydrofolate in MA104 cells is independent of folate receptor regulation.

Authors:  B A Kamen; C A Johnson; M T Wang; R G Anderson
Journal:  J Clin Invest       Date:  1989-11       Impact factor: 14.808

6.  Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein.

Authors:  L R Coney; A Tomassetti; L Carayannopoulos; V Frasca; B A Kamen; M I Colnaghi; V R Zurawski
Journal:  Cancer Res       Date:  1991-11-15       Impact factor: 12.701

7.  The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitro.

Authors:  B A Kamen; A K Smith; R G Anderson
Journal:  J Clin Invest       Date:  1991-04       Impact factor: 14.808

8.  Receptor-mediated folate accumulation is regulated by the cellular folate content.

Authors:  B A Kamen; A Capdevila
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

9.  The fine structure of the gall bladder epithelium of the mouse.

Authors:  E YAMADA
Journal:  J Biophys Biochem Cytol       Date:  1955-09-25

10.  The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway.

Authors:  K G Rothberg; Y S Ying; J F Kolhouse; B A Kamen; R G Anderson
Journal:  J Cell Biol       Date:  1990-03       Impact factor: 10.539
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  25 in total

1.  The antitumor activity of the human FOLR1-specific monoclonal antibody, farletuzumab, in an ovarian cancer mouse model is mediated by antibody-dependent cellular cytotoxicity.

Authors:  JianMin Lin; Jared L Spidel; Christopher J Maddage; Katherine A Rybinski; Rina P Kennedy; Candice L M Krauthauser; Young Chul Park; Earl F Albone; Sara Jacob; Matthew T Goserud; Bryon P Martinez; Qimin Chao; Yuhong Zhou; Nicholas C Nicolaides; J Bradford Kline; Luigi Grasso
Journal:  Cancer Biol Ther       Date:  2013-08-28       Impact factor: 4.742

2.  In vitro and in vivo targeting of different folate receptor-positive cancer cell lines with a novel 99mTc-radiofolate tracer.

Authors:  Cristina Müller; P August Schubiger; Roger Schibli
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-05-24       Impact factor: 9.236

3.  Keratinocytes constitutively express the Fas antigen that mediates apoptosis in IFN gamma-treated cultured keratinocytes.

Authors:  H Matsue; H Kobayashi; T Hosokawa; T Akitaya; A Ohkawara
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017

Review 4.  Carrier-mediated intestinal transport of drugs.

Authors:  A Tsuji; I Tamai
Journal:  Pharm Res       Date:  1996-07       Impact factor: 4.200

Review 5.  Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways.

Authors:  P W Swaan
Journal:  Pharm Res       Date:  1998-06       Impact factor: 4.200

6.  Folate receptors targeted to clathrin-coated pits cannot regulate vitamin uptake.

Authors:  T E Ritter; O Fajardo; H Matsue; R G Anderson; S W Lacey
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

7.  Transduction of folate receptor cDNA into cervical carcinoma cells using recombinant adeno-associated virions delays cell proliferation in vitro and in vivo.

Authors:  X L Sun; B R Murphy; Q J Li; S Gullapalli; J Mackins; H N Jayaram; A Srivastava; A C Antony
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

8.  Structural basis for molecular recognition of folic acid by folate receptors.

Authors:  Chen Chen; Jiyuan Ke; X Edward Zhou; Wei Yi; Joseph S Brunzelle; Jun Li; Eu-Leong Yong; H Eric Xu; Karsten Melcher
Journal:  Nature       Date:  2013-07-14       Impact factor: 49.962

9.  Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates.

Authors:  K N Chung; Y Saikawa; T H Paik; K H Dixon; T Mulligan; K H Cowan; P C Elwood
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

Review 10.  Endocytosis of glycosylphosphatidylinositol-anchored proteins.

Authors:  Shaheen E Lakhan; Shefali Sabharanjak; Ananya De
Journal:  J Biomed Sci       Date:  2009-10-15       Impact factor: 8.410
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