| Literature DB >> 16310359 |
Silvia Schenone1, Chiara Brullo, Olga Bruno, Francesco Bondavalli, Angelo Ranise, Walter Filippelli, Barbara Rinaldi, Annalisa Capuano, Giuseppe Falcone.
Abstract
Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.Entities:
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Year: 2005 PMID： 16310359 DOI： 10.1016/j.bmc.2005.10.064
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641