Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Adipose tissue as source and target for novel therapies.

Literature DB >> 16309918

Adipose tissue as source and target for novel therapies.

Johannes Klein¹, Nina Perwitz, Daniel Kraus, Mathias Fasshauer.

Abstract

The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2005 PMID： 16309918 DOI： 10.1016/j.tem.2005.11.008

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

Keyword Cloud
Cited

12 in total

1. Adipokine expression in brown and white adipocytes in response to hypoxia.

Authors: A Wree; A Mayer; S Westphal; A Beilfuss; A Canbay; R R Schick; G Gerken; P Vaupel
Journal: J Endocrinol Invest Date: 2011-09-27 Impact factor: 4.256

Review 2. The metabolic syndrome and endothelial dysfunction: common highway to type 2 diabetes and CVD.

Authors: Michaela Diamant; Maarten E Tushuizen
Journal: Curr Diab Rep Date: 2006-08 Impact factor: 4.810

3. Physical activity and hypocaloric diet recovers osteoblasts homeostasis in women affected by abdominal obesity.

Authors: Viviana M Bimonte; Simona Fittipaldi; Chiara Marocco; Gian Pietro Emerenziani; Rachele Fornari; Laura Guidetti; Eleonora Poggiogalle; Emanuele Nicolai; Luigi Di Luigi; Lorenzo M Donini; Carlo Baldari; Andrea Lenzi; Emanuela A Greco; Silvia Migliaccio
Journal: Endocrine Date: 2016-12-16 Impact factor: 3.633

4. Endoplasmic reticulum stress regulates adipocyte resistin expression.

Authors: Martina I Lefterova; Shannon E Mullican; Takuya Tomaru; Mohammed Qatanani; Michael Schupp; Mitchell A Lazar
Journal: Diabetes Date: 2009-06-02 Impact factor: 9.461

5. Negative association between trunk fat, insulin resistance and skeleton in obese women.

Authors: Emanuela A Greco; Davide Francomano; Rachele Fornari; Chiara Marocco; Carla Lubrano; Vincenza Papa; Francesca Wannenes; Luigi Di Luigi; Lorenzo M Donini; Andrea Lenzi; Antonio Aversa; Silvia Migliaccio
Journal: World J Diabetes Date: 2013-04-15

Adipose tissue as source and target for novel therapies.

1. Adipokine expression in brown and white adipocytes in response to hypoxia.

Review 2. The metabolic syndrome and endothelial dysfunction: common highway to type 2 diabetes and CVD.

3. Physical activity and hypocaloric diet recovers osteoblasts homeostasis in women affected by abdominal obesity.

4. Endoplasmic reticulum stress regulates adipocyte resistin expression.

5. Negative association between trunk fat, insulin resistance and skeleton in obese women.

6. Differentiation of human adipose tissue SVF cells into cardiomyocytes.

7. Human adipose tissue stromal vascular fraction cells differentiate depending on distinct types of media.

8. Selection of aptamers specific for adipose tissue.

9. Effect of weight loss on adipokine levels in obese patients.

10. Cortisol secretion after adrenocorticotrophin (ACTH) and dexamethasone tests in healthy female and male dogs.