Literature DB >> 16304189

Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways.

Nathan P Wiederhold1, Dimitrios P Kontoyiannis, Randall A Prince, Russell E Lewis.   

Abstract

Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 microg/ml. This phenomenon was markedly attenuated in a deltamkc1/deltamkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these caspofungin concentrations resulted in MKC1 up-regulation, suggesting roles of cell wall integrity and calcineurin pathways.

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Year:  2005        PMID： 16304189      PMCID： PMC1315970          DOI： 10.1128/AAC.49.12.5146-5148.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  The yeast protein kinase C cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of Slt2p mitogen-activated protein kinase signaling.

Authors:  Cristina Reinoso-Martín; Christoph Schüller; Manuela Schuetzer-Muehlbauer; Karl Kuchler
Journal:  Eukaryot Cell       Date:  2003-12

2.  Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae.

Authors:  Sarit Markovich; Aya Yekutiel; Itamar Shalit; Yona Shadkchan; Nir Osherov
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

3.  Isogenic strain construction and gene mapping in Candida albicans.

Authors:  W A Fonzi; M Y Irwin
Journal:  Genetics       Date:  1993-07       Impact factor: 4.562

4.  In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies.

Authors:  Gordon Ramage; Kacy VandeWalle; Stefano P Bachmann; Brian L Wickes; José L López-Ribot
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

5.  Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations.

Authors:  David A Stevens; Marife Espiritu; Rachana Parmar
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

6.  Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity.

Authors:  F Navarro-García; M Sánchez; J Pla; C Nombela
Journal:  Mol Cell Biol       Date:  1995-04       Impact factor: 4.272

7.  Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity.

Authors:  Nathan P Wiederhold; Dimitrios P Kontoyiannis; Jingduan Chi; Randall A Prince; Vincent H Tam; Russell E Lewis
Journal:  J Infect Dis       Date:  2004-09-10       Impact factor: 5.226

8.  Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae.

Authors:  Ameeta K Agarwal; P David Rogers; Scott R Baerson; Melissa R Jacob; Katherine S Barker; John D Cleary; Larry A Walker; Dale G Nagle; Alice M Clark
Journal:  J Biol Chem       Date:  2003-06-24       Impact factor: 5.157

9.  Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species.

Authors:  Dimitrios P Kontoyiannis; Russell E Lewis; Nir Osherov; Nathaniel D Albert; Gregory S May
Journal:  J Antimicrob Chemother       Date:  2003-02       Impact factor: 5.790

10.  Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase.

Authors:  P Mazur; N Morin; W Baginsky; M el-Sherbeini; J A Clemas; J B Nielsen; F Foor
Journal:  Mol Cell Biol       Date:  1995-10       Impact factor: 4.272
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  56 in total

Review 1.  Echinocandins for the Treatment of Invasive Aspergillosis: from Laboratory to Bedside.

Authors:  Marion Aruanno; Emmanouil Glampedakis; Frédéric Lamoth
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

2.  The Rim Pathway Mediates Antifungal Tolerance in Candida albicans through Newly Identified Rim101 Transcriptional Targets, Including Hsp90 and Ipt1.

Authors:  Cécile Garnaud; Encar García-Oliver; Yan Wang; Danièle Maubon; Sébastien Bailly; Quentin Despinasse; Morgane Champleboux; Jérôme Govin; Muriel Cornet
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

3.  Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.

Authors:  David A Stevens; Masayuki Ichinomiya; Yukako Koshi; Hiroyuki Horiuchi
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

Review 4.  Mitogen-activated protein kinase pathways and fungal pathogenesis.

Authors:  Xinhua Zhao; Rahim Mehrabi; Jin-Rong Xu
Journal:  Eukaryot Cell       Date:  2007-08-22

5.  Trailing or paradoxical growth of Candida albicans when exposed to caspofungin is not associated with microsatellite genotypes.

Authors:  Mohamed Khlif; Hervé Bogreau; Annie Michel-Nguyen; Ali Ayadi; Stéphane Ranque
Journal:  Antimicrob Agents Chemother       Date:  2010-01-11       Impact factor: 5.191

Review 6.  Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Authors:  Leah E Cowen; William J Steinbach
Journal:  Eukaryot Cell       Date:  2008-03-28

7.  Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum.

Authors:  Ryan K Shields; M Hong Nguyen; Chen Du; Ellen Press; Shaoji Cheng; Cornelius J Clancy
Journal:  Antimicrob Agents Chemother       Date:  2011-03-21       Impact factor: 5.191

Review 8.  Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins.

Authors:  Brigitte M E Hayes; Marilyn A Anderson; Ana Traven; Nicole L van der Weerden; Mark R Bleackley
Journal:  Cell Mol Life Sci       Date:  2014-02-14       Impact factor: 9.261

9.  Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus.

Authors:  Frédéric Lamoth; Praveen R Juvvadi; Christopher Gehrke; Yohannes G Asfaw; William J Steinbach
Journal:  J Infect Dis       Date:  2013-10-04       Impact factor: 5.226

10.  Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

Authors:  Sheena D Singh; Nicole Robbins; Aimee K Zaas; Wiley A Schell; John R Perfect; Leah E Cowen
Journal:  PLoS Pathog       Date:  2009-07-31       Impact factor: 6.823
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