| Literature DB >> 16303309 |
A F Moretto1, S J Kirincich, W X Xu, M J Smith, Z-K Wan, D P Wilson, B C Follows, E Binnun, D Joseph-McCarthy, K Foreman, D V Erbe, Y L Zhang, S K Tam, S Y Tam, J Lee.
Abstract
A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallography and molecular modeling. Excellent consistency has been observed between structure-activity relationships and structural information from PTP1B-inhibitor complexes.Entities:
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Year: 2005 PMID： 16303309 DOI： 10.1016/j.bmc.2005.11.005
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641