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Literature DB >> 16290136

Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key.

Tanya Vavouri¹, Gayle K McEwen, Adam Woolfe, Walter R Gilks, Greg Elgar.

Abstract

Many conserved non-coding elements (CNEs) in vertebrate genomes have been shown to function as tissue-specific enhancers. However, the target genes of most CNEs are unknown. Here we show that the target genes of duplicated CNEs can be predicted by considering their neighbouring paralogous genes. This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene.

Entities: Chemical

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Year: 2005 PMID： 16290136 DOI： 10.1016/j.tig.2005.10.005

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

34 in total

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Journal: Genome Res Date: 2007-03-26 Impact factor: 9.043

4. Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.

Authors: Jean M Winter; Derek E Gildea; Jonathan P Andreas; Daniel M Gatti; Kendra A Williams; Minnkyong Lee; Ying Hu; Suiyuan Zhang; James C Mullikin; Tyra G Wolfsberg; Shannon K McDonnell; Zachary C Fogarty; Melissa C Larson; Amy J French; Daniel J Schaid; Stephen N Thibodeau; Gary A Churchill; Nigel P S Crawford
Journal: Cell Syst Date: 2016-12-01 Impact factor: 10.304

Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key.

Review 1. From genes to function: the next challenge to understanding multiple sclerosis.

Review 2. Long non-coding RNA in health and disease.

3. Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates.

4. Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.

5. A misplaced lncRNA causes brachydactyly in humans.

Review 6. Genetics of type 1 diabetes: what's next?

Review 7. The emerging genetic architecture of type 2 diabetes.

8. Long-range regulation is a major driving force in maintaining genome integrity.

9. Correlated changes between regulatory cis elements and condition-specific expression in paralogous gene families.

10. Ancient duplicated conserved noncoding elements in vertebrates: a genomic and functional analysis.