| Literature DB >> 16289004 |
Fang Liu1.
Abstract
Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family members, Smad3 is the only CDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function. Because cancer cells often contain high levels of CDK activity, inhibition of Smad activity by CDK phosphorylation may contribute to tumorigenesis and TGF-beta resistance in cancers.Entities:
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Year: 2005 PMID： 16289004 DOI： 10.1016/j.cytogfr.2005.09.010
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638