OBJECTIVE: Alzheimer disease (AD) is the leading cause of dementia in older persons, but little is known about racial differences in its clinical manifestations. The purpose of the current study was to examine the association of race with rate of cognitive decline in AD. METHODS: Older persons with clinically diagnosed AD were recruited from healthcare settings. At 6-month intervals for up to 4 years, they completed a battery of nine cognitive tests from which a previously established measure of global cognition was derived. Follow-up data were available on 452 participants (27.6% African American, 68.8% women), 88.1% of those eligible. RESULTS: A growth curve approach was used to estimate individual paths of change in global cognition. In a model that controlled for age and education, African Americans had a lower level of global cognition at baseline than non-African Americans, but declined at a 25% slower rate on average. In additional models, there was no indication that the association of race with cognitive decline varied by age, gender, or education. CONCLUSION: The rate of cognitive decline in AD appears to be slower in African Americans than non-African Americans.
OBJECTIVE: Alzheimer disease (AD) is the leading cause of dementia in older persons, but little is known about racial differences in its clinical manifestations. The purpose of the current study was to examine the association of race with rate of cognitive decline in AD. METHODS: Older persons with clinically diagnosed AD were recruited from healthcare settings. At 6-month intervals for up to 4 years, they completed a battery of nine cognitive tests from which a previously established measure of global cognition was derived. Follow-up data were available on 452 participants (27.6% African American, 68.8% women), 88.1% of those eligible. RESULTS: A growth curve approach was used to estimate individual paths of change in global cognition. In a model that controlled for age and education, African Americans had a lower level of global cognition at baseline than non-African Americans, but declined at a 25% slower rate on average. In additional models, there was no indication that the association of race with cognitive decline varied by age, gender, or education. CONCLUSION: The rate of cognitive decline in AD appears to be slower in African Americans than non-African Americans.
Authors: Jesse Mez; Jaeyoon Chung; Gyungah Jun; Joshua Kriegel; Alexandra P Bourlas; Richard Sherva; Mark W Logue; Lisa L Barnes; David A Bennett; Joseph D Buxbaum; Goldie S Byrd; Paul K Crane; Nilüfer Ertekin-Taner; Denis Evans; M Daniele Fallin; Tatiana Foroud; Alison Goate; Neill R Graff-Radford; Kathleen S Hall; M Ilyas Kamboh; Walter A Kukull; Eric B Larson; Jennifer J Manly; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Gerard D Schellenberg; Kathryn L Lunetta; Lindsay A Farrer Journal: Alzheimers Dement Date: 2016-10-20 Impact factor: 21.566
Authors: Aron S Buchman; Lei Yu; Robert S Wilson; Patricia A Boyle; Julie A Schneider; David A Bennett Journal: J Gerontol A Biol Sci Med Sci Date: 2014-08-18 Impact factor: 6.053
Authors: Shannon Sisco; Alden L Gross; Regina A Shih; Bonnie C Sachs; M Maria Glymour; Katherine J Bangen; Andreana Benitez; Jeannine Skinner; Brooke C Schneider; Jennifer J Manly Journal: J Gerontol B Psychol Sci Soc Sci Date: 2014-02-28 Impact factor: 4.077
Authors: Ganesh M Babulal; Yakeel T Quiroz; Benedict C Albensi; Eider Arenaza-Urquijo; Arlene J Astell; Claudio Babiloni; Alex Bahar-Fuchs; Joanne Bell; Gene L Bowman; Adam M Brickman; Gaël Chételat; Carrie Ciro; Ann D Cohen; Peggye Dilworth-Anderson; Hiroko H Dodge; Simone Dreux; Steven Edland; Anna Esbensen; Lisbeth Evered; Michael Ewers; Keith N Fargo; Juan Fortea; Hector Gonzalez; Deborah R Gustafson; Elizabeth Head; James A Hendrix; Scott M Hofer; Leigh A Johnson; Roos Jutten; Kerry Kilborn; Krista L Lanctôt; Jennifer J Manly; Ralph N Martins; Michelle M Mielke; Martha Clare Morris; Melissa E Murray; Esther S Oh; Mario A Parra; Robert A Rissman; Catherine M Roe; Octavio A Santos; Nikolaos Scarmeas; Lon S Schneider; Nicole Schupf; Sietske Sikkes; Heather M Snyder; Hamid R Sohrabi; Yaakov Stern; Andre Strydom; Yi Tang; Graciela Muniz Terrera; Charlotte Teunissen; Debora Melo van Lent; Michael Weinborn; Linda Wesselman; Donna M Wilcock; Henrik Zetterberg; Sid E O'Bryant Journal: Alzheimers Dement Date: 2018-12-13 Impact factor: 21.566
Authors: Neha Sinha; Zachariah M Reagh; Nicholas J Tustison; Chelsie N Berg; Ashlee Shaw; Catherine E Myers; Diane Hill; Michael A Yassa; Mark A Gluck Journal: Hippocampus Date: 2018-12-10 Impact factor: 3.899
Authors: Justina F Avila; Jet M J Vonk; Steven P Verney; Katie Witkiewitz; Miguel Arce Rentería; Nicole Schupf; Richard Mayeux; Jennifer J Manly Journal: Alzheimers Dement Date: 2019-10-09 Impact factor: 21.566