| Literature DB >> 16277483 |
Lin Wang1, Chaoyong James Yang, Colin D Medley, Steven A Benner, Weihong Tan.
Abstract
A novel LNA-MB (molecular beacon based on locked nucleic acid bases) has been designed and investigated. It exhibits very high melting temperature and is thermally stable, shows superior single base mismatch discrimination capability, and is stable against digestion by nuclease and has no binding with single-stranded DNA binding proteins. The LNA-MB will be widely useful in a variety of areas, especially for in vivo hybridization studies.Mesh：
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Year: 2005 PMID： 16277483 DOI： 10.1021/ja052498g
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419