| Literature DB >> 16276065 |
Osamu Taira1, Itsuki Watanugi, Yuko Hagiwara, Masaki Takahashi, Setsuo Arai, Hisaaki Sato, Nobutoshi Maehara.
Abstract
We cloned five new subtypes of cDNA encoding canine interferon-alpha (CaIFN-alpha) from a canine epithelial cell line. CaIFN-alphas were divided into two groups by amino acid sequences and a molecular phylogenic tree. Two subtypes of them were expressed in Escherichia coli, and IFN proteins were purified. Recombinant CaIFN-alphas were highly species-specific and showed antiviral activity against Vesicular stomatitis New Jersey virus and canine adenovirus-1 , but not against canine herpesvirus-1.Entities:
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Year: 2005 PMID： 16276065 DOI： 10.1292/jvms.67.1059
Source DB: PubMed Journal: J Vet Med Sci ISSN： 0916-7250 Impact factor: 1.267