| Literature DB >> 16271417 |
Ruairi Friel1, Sjaak van der Sar, Patrick J Mee.
Abstract
Embryonic stem cells offer enormous potential as a source of a variety of differentiated cells for cell therapy, drug discovery and toxicology screening. With the creation of human embryonic stem cell lines we now have a resource with the potential to differentiate into every tissue of the body. To fully harness this resource it is necessary to understand their biology. Here we give a background to their history, describe interesting elements of their cell biology and introduce the underlying signalling mechanisms that control their ability to self-renew and differentiate.Entities:
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Year: 2005 PMID： 16271417 DOI： 10.1016/j.addr.2005.08.002
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470