| Literature DB >> 16269324 |
Nancy M Bonini1, Benoit I Giasson.
Abstract
It is well established that the abundant neuronal protein alpha-synuclein has a causal role in Parkinson's disease, yet the normal functions of this protein remain unclear. In this issue of Cell, Chandra et al. (2005) reveal that alpha-synuclein acts as a molecular chaperone, assisting in the folding and refolding of synaptic proteins called SNAREs. These proteins are crucial for release of neurotransmitters at the neuronal synapse, vesicle recycling, and synaptic integrity.Entities:
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Year: 2005 PMID： 16269324 DOI： 10.1016/j.cell.2005.10.017
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582