Literature DB >> 16267693

Secure analysis of distributed chemical databases without data integration.

Alan F Karr1, Jun Feng, Xiaodong Lin, Ashish P Sanil, S Stanley Young, Jerome P Reiter.   

Abstract

We present a method for performing statistically valid linear regressions on the union of distributed chemical databases that preserves confidentiality of those databases. The method employs secure multi-party computation to share local sufficient statistics necessary to compute least squares estimators of regression coefficients, error variances and other quantities of interest. We illustrate our method with an example containing four companies' rather different databases.

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Year:  2005        PMID: 16267693     DOI: 10.1007/s10822-005-9011-5

Source DB:  PubMed          Journal:  J Comput Aided Mol Des        ISSN: 0920-654X            Impact factor:   3.686


  2 in total

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Authors: 
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Authors:  Kejun Liu; Jun Feng; S Stanley Young
Journal:  J Chem Inf Model       Date:  2005 Mar-Apr       Impact factor: 4.956

  2 in total
  7 in total

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Journal:  J Biomed Inform       Date:  2013-04-04       Impact factor: 6.317

2.  Bigger data, collaborative tools and the future of predictive drug discovery.

Authors:  Sean Ekins; Alex M Clark; S Joshua Swamidass; Nadia Litterman; Antony J Williams
Journal:  J Comput Aided Mol Des       Date:  2014-06-19       Impact factor: 3.686

3.  A secure distributed logistic regression protocol for the detection of rare adverse drug events.

Authors:  Khaled El Emam; Saeed Samet; Luk Arbuckle; Robyn Tamblyn; Craig Earle; Murat Kantarcioglu
Journal:  J Am Med Inform Assoc       Date:  2012-08-07       Impact factor: 4.497

4.  Distributed Regression Analysis Application in Large Distributed Data Networks: Analysis of Precision and Operational Performance.

Authors:  Qoua Her; Jessica Malenfant; Zilu Zhang; Yury Vilk; Jessica Young; David Tabano; Jack Hamilton; Ron Johnson; Marsha Raebel; Denise Boudreau; Sengwee Toh
Journal:  JMIR Med Inform       Date:  2020-06-04

5.  Bidirectional Data Collaborations in Distributed Research.

Authors:  Kevin Haynes; Nandini Selvam; Mark J Cziraky
Journal:  EGEMS (Wash DC)       Date:  2016-03-22

6.  Secure Multi-pArty Computation Grid LOgistic REgression (SMAC-GLORE).

Authors:  Haoyi Shi; Chao Jiang; Wenrui Dai; Xiaoqian Jiang; Yuzhe Tang; Lucila Ohno-Machado; Shuang Wang
Journal:  BMC Med Inform Decis Mak       Date:  2016-07-25       Impact factor: 2.796

7.  BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry.

Authors:  Igor V Tetko; Ola Engkvist; Uwe Koch; Jean-Louis Reymond; Hongming Chen
Journal:  Mol Inform       Date:  2016-07-28       Impact factor: 3.353

  7 in total

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