| Literature DB >> 16266126 |
Adinarayana Gorajana1, Bapiraju V V S N Kurada, Sujatha Peela, Premkumar Jangam, Saisha Vinjamuri, Ellaiah Poluri, Axel Zeeck.
Abstract
In our systematic screening programme for marine actinomycetes, a bioactive streptomycete was isolated from marine sediment samples of the Bay of Bengal, India. The isolate yielded a new cytotoxic compound. This was obtained by solvent extraction followed by chromatographic purification. The pure compound was identified from spectroscopic data as a quinone-related antibiotic, 1-hydroxy-1-norresistomycin (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (gastric adenocarcinoma) and HePG2 (hepatic carcinoma) in vitro. It also exhibited antibacterial activities against Gram-positive and Gram-negative bacteria.Entities:
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Year: 2005 PMID： 16266126 DOI： 10.1038/ja.2005.72
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649