Literature DB >> 16263933

Targeted down-regulation of cytochrome P450 enzymes for forage quality improvement in alfalfa (Medicago sativa L.).

M S Srinivasa Reddy1, Fang Chen, Gail Shadle, Lisa Jackson, Hugh Aljoe, Richard A Dixon.   

Abstract

Improving the digestibility of forages provides a means to enhance animal performance and protect the environment against excessive animal waste. Increased lignin content during maturity, and corresponding changes in lignin composition, correlate with decreased digestibility of forages. These relationships have yet to be investigated in isogenic systems. By targeting three specific cytochrome P450 enzymes of the lignin pathway for antisense down-regulation, we generated transgenic alfalfa lines with a range of differences in lignin content and composition. There was a strong negative relationship between lignin content and rumen digestibility, but no relationship between lignin composition and digestibility, in these transgenic lines. Models for genetic manipulation of forage digestibility based on the changes in lignin composition that increase paper-pulping efficiency in trees are therefore invalid. Down-regulation of 4-coumarate 3-hydroxylase provided the largest improvements in digestibility yet seen in a forage crop.

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Year:  2005        PMID： 16263933      PMCID： PMC1283808          DOI： 10.1073/pnas.0505749102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

Review 1.  Stacking transgenes in forest trees.

Authors:  Claire Halpin; Wout Boerjan
Journal:  Trends Plant Sci       Date:  2003-08       Impact factor: 18.313

2.  Altering expression of cinnamic acid 4-hydroxylase in transgenic plants provides evidence for a feedback loop at the entry point into the phenylpropanoid pathway.

Authors:  J W Blount; K L Korth; S A Masoud; S Rasmussen; C Lamb; R A Dixon
Journal:  Plant Physiol       Date:  2000-01       Impact factor: 8.340

3.  Influence of lignin on digestibility of forage cell wall material.

Authors:  H G Jung; K P Vogel
Journal:  J Anim Sci       Date:  1986-06       Impact factor: 3.159

4.  In situ analysis of lignins in transgenic tobacco reveals a differential impact of individual transformations on the spatial patterns of lignin deposition at the cellular and subcellular levels.

Authors:  M Chabannes; K Ruel; A Yoshinaga; B Chabbert; A Jauneau; J P Joseleau; A M Boudet
Journal:  Plant J       Date:  2001-11       Impact factor: 6.417

5.  Purification, cloning, and properties of an acyltransferase controlling shikimate and quinate ester intermediates in phenylpropanoid metabolism.

Authors:  Laurent Hoffmann; Stephane Maury; Francoise Martz; Pierrette Geoffroy; Michel Legrand
Journal:  J Biol Chem       Date:  2002-10-14       Impact factor: 5.157

6.  Elucidation of factors associated with the maturity-related decline in degradability of big bluestem cell wall.

Authors:  E C Titgemeyer; R C Cochran; E G Towne; C K Armendariz; K C Olson
Journal:  J Anim Sci       Date:  1996-03       Impact factor: 3.159

7.  New routes for lignin biosynthesis defined by biochemical characterization of recombinant ferulate 5-hydroxylase, a multifunctional cytochrome P450-dependent monooxygenase.

Authors:  J M Humphreys; M R Hemm; C Chapple
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

8.  Improvement of in-rumen digestibility of alfalfa forage by genetic manipulation of lignin O-methyltransferases.

Authors:  D Guo; F Chen; J Wheeler; J Winder; S Selman; M Peterson; R A Dixon
Journal:  Transgenic Res       Date:  2001-10       Impact factor: 2.788

9.  The Arabidopsis thaliana REDUCED EPIDERMAL FLUORESCENCE1 gene encodes an aldehyde dehydrogenase involved in ferulic acid and sinapic acid biosynthesis.

Authors:  Ramesh B Nair; Kristen L Bastress; Max O Ruegger; Jeff W Denault; Clint Chapple
Journal:  Plant Cell       Date:  2004-01-16       Impact factor: 11.277

10.  Silencing of hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyltransferase affects phenylpropanoid biosynthesis.

Authors:  Laurent Hoffmann; Sébastien Besseau; Pierrette Geoffroy; Christophe Ritzenthaler; Denise Meyer; Catherine Lapierre; Brigitte Pollet; Michel Legrand
Journal:  Plant Cell       Date:  2004-05-25       Impact factor: 11.277
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  85 in total

1.  Increase in 4-coumaryl alcohol units during lignification in alfalfa (Medicago sativa) alters the extractability and molecular weight of lignin.

Authors:  Angela Ziebell; Kristen Gracom; Rui Katahira; Fang Chen; Yunqiao Pu; Art Ragauskas; Richard A Dixon; Mark Davis
Journal:  J Biol Chem       Date:  2010-10-04       Impact factor: 5.157

2.  A polymer of caffeyl alcohol in plant seeds.

Authors:  Fang Chen; Yuki Tobimatsu; Daphna Havkin-Frenkel; Richard A Dixon; John Ralph
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

3.  Artificial miRNA-mediated down-regulation of two monolignoid biosynthetic genes (C3H and F5H) cause reduction in lignin content in jute.

Authors:  Farhana Shafrin; Sudhanshu Sekhar Das; Neeti Sanan-Mishra; Haseena Khan
Journal:  Plant Mol Biol       Date:  2015-10-09       Impact factor: 4.076

4.  Integration of renewable deep eutectic solvents with engineered biomass to achieve a closed-loop biorefinery.

Authors:  Kwang Ho Kim; Aymerick Eudes; Keunhong Jeong; Chang Geun Yoo; Chang Soo Kim; Arthur Ragauskas
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-24       Impact factor: 11.205

5.  RNAi-mediated suppression of p-coumaroyl-CoA 3'-hydroxylase in hybrid poplar impacts lignin deposition and soluble secondary metabolism.

Authors:  Heather D Coleman; Ji-Young Park; Ramesh Nair; Clint Chapple; Shawn D Mansfield
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-03       Impact factor: 11.205

6.  Profile of Richard Dixon.

Authors:  Melissa Marino
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-12       Impact factor: 11.205

7.  Lignin modification leads to increased nodule numbers in alfalfa.

Authors:  Lina Gallego-Giraldo; Kishor Bhattarai; Catalina I Pislariu; Jin Nakashima; Yusuke Jikumaru; Yuji Kamiya; Michael K Udvardi; Maria J Monteros; Richard A Dixon
Journal:  Plant Physiol       Date:  2014-01-09       Impact factor: 8.340

Review 8.  Biotechnological advancements in alfalfa improvement.

Authors:  Suresh Kumar
Journal:  J Appl Genet       Date:  2011-01-29       Impact factor: 3.240

9.  SG2-Type R2R3-MYB Transcription Factor MYB15 Controls Defense-Induced Lignification and Basal Immunity in Arabidopsis.

Authors:  William R Chezem; Altamash Memon; Fu-Shuang Li; Jing-Ke Weng; Nicole K Clay
Journal:  Plant Cell       Date:  2017-07-21       Impact factor: 11.277

10.  QTL detection for forage quality and stem histology in four connected mapping populations of the model legume Medicago truncatula.

Authors:  Luz Del Carmen Lagunes Espinoza; Bernadette Julier
Journal:  Theor Appl Genet       Date:  2012-10-26       Impact factor: 5.699
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