Literature DB >> 16263280

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library.

Patricia Melnyk1, Virginie Leroux, Christian Sergheraert, Philippe Grellier.   

Abstract

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.

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Year:  2005        PMID： 16263280     DOI： 10.1016/j.bmcl.2005.09.058

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  31 in total

1.  Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells.

Authors:  Kyu Kwang Kim; Thilo S Lange; Rakesh K Singh; Laurent Brard
Journal:  BMC Cancer       Date:  2010-02-25       Impact factor: 4.430

2.  Synthesis, characterization and anticancer activities of transition metal complexes with a nicotinohydrazone ligand.

Authors:  Shanshan Shen; Hong Chen; Taofeng Zhu; Xiuqin Ma; Jun Xu; Wenjiao Zhu; Ruhua Chen; Jing Xie; Tieliang Ma; Lei Jia; Yuan Wang; Chunyan Peng
Journal:  Oncol Lett       Date:  2017-03-14       Impact factor: 2.967

3.  Study of Binding Properties Between Two New Ibuprofen and Naproxen Based Acyl Hydrazone Derivatives and Trypsin.

Authors:  Elmas Gökoğlu; Esra Yılmaz; Esra Gökoğlu; Ayşe Uzgören Baran
Journal:  J Fluoresc       Date:  2016-01       Impact factor: 2.217

4.  Development of novel Asf1-H3/H4 inhibitors.

Authors:  Greg F Miknis; Sarah J Stevens; Luke E Smith; David A Ostrov; Mair E A Churchill
Journal:  Bioorg Med Chem Lett       Date:  2014-12-04       Impact factor: 2.823

5.  Microwave-assisted synthesis and evaluation of acylhydrazones as potential inhibitors of bovine glutathione peroxidase.

Authors:  Felix Wilde; Heidi Lemmerhirt; Thomas Emmrich; Patrick J Bednarski; Andreas Link
Journal:  Mol Divers       Date:  2014-01-19       Impact factor: 2.943

6.  Spectro Analytical, Computational and In Vitro Biological Studies of Novel Substituted Quinolone Hydrazone and it's Metal Complexes.

Authors:  Narsimha Nagula; Sudeepa Kunche; Mohmed Jaheer; Ravi Mudavath; Sreekanth Sivan; Sarala Devi Ch
Journal:  J Fluoresc       Date:  2017-11-21       Impact factor: 2.217

7.  Computer-aided design of novel antibacterial 3-hydroxypyridine-4-ones: application of QSAR methods based on the MOLMAP approach.

Authors:  Razieh Sabet; Afshin Fassihi; Bahram Hemmateenejad; Lotfollah Saghaei; Ramin Miri; Maryam Gholami
Journal:  J Comput Aided Mol Des       Date:  2012-03-28       Impact factor: 3.686

8.  HPLC analysis of in vivo metabolites of 4-nitrobenzoic acid [(5-nitro-2-thiopheneyl)methylene]hydrazide in rats.

Authors:  Bedia Koçyiğit-Kaymakçioğlu; Seda Unsalan; S Güniz Küçükgüzel; Göksel Sener; Sevim Rollas
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2007 Oct-Dec       Impact factor: 2.441

9.  (E)-4-Hydr-oxy-N'-(2-hydr-oxy-4-methoxy-benzyl-idene)benzohydrazide monohydrate.

Authors:  Nooraziah Mohd Lair; Hapipah Mohd Ali; Seik Weng Ng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-12-20

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
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