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Literature DB >> 16261567

Noradrenergic modulation of space exploration in visual neglect.

Paresh A Malhotra¹, Andrew D Parton, Richard Greenwood, Masud Husain.

Abstract

Visual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, a noradrenergic agonist that modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right-hemisphere patients with neglect. The positive effects of guanfacine were associated with extended ability to maintain attention on task. The results suggest that neuropharmacological targeting of intact frontal areas might be one way to enhance cognitive function after damage to posterior brain regions in selected individuals.

Entities: Chemical Disease Species

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Year: 2006 PMID： 16261567 DOI： 10.1002/ana.20701

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

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Cited

31 in total

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3. Differences in theta coherence between spatial and nonspatial attention using intracranial electroencephalographic signals in humans.

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4. DTI-MR tractography of white matter damage in stroke patients with neglect.

Authors: M Urbanski; M Thiebaut de Schotten; S Rodrigo; C Oppenheim; E Touzé; J-F Méder; K Moreau; C Loeper-Jeny; B Dubois; P Bartolomeo
Journal: Exp Brain Res Date: 2010-11-27 Impact factor: 1.972

Review 5. Aphasia and right hemisphere syndromes in stroke.

Authors: Lori C Jordan; Argye E Hillis
Journal: Curr Neurol Neurosci Rep Date: 2005-11 Impact factor: 5.081

Review 6. Spatial neglect: clinical and neuroscience review: a wealth of information on the poverty of spatial attention.

Authors: John C Adair; Anna M Barrett
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7. The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke.

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Noradrenergic modulation of space exploration in visual neglect.

Review 1. The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder.

2. Pleasant music overcomes the loss of awareness in patients with visual neglect.

3. Differences in theta coherence between spatial and nonspatial attention using intracranial electroencephalographic signals in humans.

4. DTI-MR tractography of white matter damage in stroke patients with neglect.

Review 5. Aphasia and right hemisphere syndromes in stroke.

Review 6. Spatial neglect: clinical and neuroscience review: a wealth of information on the poverty of spatial attention.

7. The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke.

8. Rehabilitation of spatial neglect.

9. The functional role of the inferior parietal lobe in the dorsal and ventral stream dichotomy.

Review 10. Pharmacological interventions for unilateral spatial neglect after stroke.

Noradrenergic modulation of space exploration in visual neglect.

Review 1. The use of &#x03B1;-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder.

2. Pleasant music overcomes the loss of awareness in patients with visual neglect.

3. Differences in theta coherence between spatial and nonspatial attention using intracranial electroencephalographic signals in humans.

4. DTI-MR tractography of white matter damage in stroke patients with neglect.

Review 5. Aphasia and right hemisphere syndromes in stroke.

Review 6. Spatial neglect: clinical and neuroscience review: a wealth of information on the poverty of spatial attention.

7. The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke.

8. Rehabilitation of spatial neglect.

9. The functional role of the inferior parietal lobe in the dorsal and ventral stream dichotomy.

Review 10. Pharmacological interventions for unilateral spatial neglect after stroke.

Review 1. The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder.