Literature DB >> 16261168

Autism spectrum disorders associated with X chromosome markers in French-Canadian males.

J Gauthier1, R Joober, M-P Dubé, J St-Onge, A Bonnel, D Gariépy, S Laurent, R Najafee, H Lacasse, L St-Charles, E Fombonne, L Mottron, G A Rouleau.   

Abstract

It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.

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Year:  2006        PMID： 16261168     DOI： 10.1038/sj.mp.4001756

Source DB:  PubMed          Journal:  Mol Psychiatry        ISSN： 1359-4184            Impact factor:   15.992


  10 in total

1.  Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.

Authors:  A Piton; J Gauthier; F F Hamdan; R G Lafrenière; Y Yang; E Henrion; S Laurent; A Noreau; P Thibodeau; L Karemera; D Spiegelman; F Kuku; J Duguay; L Destroismaisons; P Jolivet; M Côté; K Lachapelle; O Diallo; A Raymond; C Marineau; N Champagne; L Xiong; C Gaspar; J-B Rivière; J Tarabeux; P Cossette; M-O Krebs; J L Rapoport; A Addington; L E Delisi; L Mottron; R Joober; E Fombonne; P Drapeau; G A Rouleau
Journal:  Mol Psychiatry       Date:  2010-05-18       Impact factor: 15.992

2.  Posterior cingulate cortex reveals an expression profile of resilience in cognitively intact elders.

Authors:  Christy M Kelley; Stephen D Ginsberg; Winnie S Liang; Scott E Counts; Elliott J Mufson
Journal:  Brain Commun       Date:  2022-06-21

3.  Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation.

Authors:  Raman P Nagarajan; Amber R Hogart; Ynnez Gwye; Michelle R Martin; Janine M LaSalle
Journal:  Epigenetics       Date:  2006 Oct-Dec       Impact factor: 4.528

4.  Methyl-CpG-binding protein 2 polymorphisms and vulnerability to autism.

Authors:  C S Loat; S Curran; C M Lewis; J Duvall; D Geschwind; P Bolton; I W Craig
Journal:  Genes Brain Behav       Date:  2008-10       Impact factor: 3.449

5.  A genome-wide linkage and association scan reveals novel loci for autism.

Authors:  Lauren A Weiss; Dan E Arking; Mark J Daly; Aravinda Chakravarti
Journal:  Nature       Date:  2009-10-08       Impact factor: 49.962

6.  Identification of common genetic risk variants for autism spectrum disorder.

Authors:  Jakob Grove; Stephan Ripke; Thomas D Als; Manuel Mattheisen; Raymond K Walters; Hyejung Won; Jonatan Pallesen; Esben Agerbo; Ole A Andreassen; Richard Anney; Swapnil Awashti; Rich Belliveau; Francesco Bettella; Joseph D Buxbaum; Jonas Bybjerg-Grauholm; Marie Bækvad-Hansen; Felecia Cerrato; Kimberly Chambert; Jane H Christensen; Claire Churchhouse; Karin Dellenvall; Ditte Demontis; Silvia De Rubeis; Bernie Devlin; Srdjan Djurovic; Ashley L Dumont; Jacqueline I Goldstein; Christine S Hansen; Mads Engel Hauberg; Mads V Hollegaard; Sigrun Hope; Daniel P Howrigan; Hailiang Huang; Christina M Hultman; Lambertus Klei; Julian Maller; Joanna Martin; Alicia R Martin; Jennifer L Moran; Mette Nyegaard; Terje Nærland; Duncan S Palmer; Aarno Palotie; Carsten Bøcker Pedersen; Marianne Giørtz Pedersen; Timothy dPoterba; Jesper Buchhave Poulsen; Beate St Pourcain; Per Qvist; Karola Rehnström; Abraham Reichenberg; Jennifer Reichert; Elise B Robinson; Kathryn Roeder; Panos Roussos; Evald Saemundsen; Sven Sandin; F Kyle Satterstrom; George Davey Smith; Hreinn Stefansson; Stacy Steinberg; Christine R Stevens; Patrick F Sullivan; Patrick Turley; G Bragi Walters; Xinyi Xu; Kari Stefansson; Daniel H Geschwind; Merete Nordentoft; David M Hougaard; Thomas Werge; Ole Mors; Preben Bo Mortensen; Benjamin M Neale; Mark J Daly; Anders D Børglum
Journal:  Nat Genet       Date:  2019-02-25       Impact factor: 38.330

7.  Analysis of X chromosome inactivation in autism spectrum disorders.

Authors:  Xiaohong Gong; Elena Bacchelli; Francesca Blasi; Claudio Toma; Catalina Betancur; Pauline Chaste; Richard Delorme; Christelle M Durand; Fabien Fauchereau; Hany Goubran Botros; Marion Leboyer; Marie-Christine Mouren-Simeoni; Gudrun Nygren; Henrik Anckarsäter; Maria Rastam; I Carina Gillberg; Christopher Gillberg; Daniel Moreno-De-Luca; Simona Carone; Ilona Nummela; Mari Rossi; Agatino Battaglia; Irma Jarvela; Elena Maestrini; Thomas Bourgeron
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2008-09-05       Impact factor: 3.568

8.  Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability.

Authors:  Abdul Noor; Annabel Whibley; Christian R Marshall; Peter J Gianakopoulos; Amelie Piton; Andrew R Carson; Marija Orlic-Milacic; Anath C Lionel; Daisuke Sato; Dalila Pinto; Irene Drmic; Carolyn Noakes; Lili Senman; Xiaoyun Zhang; Rong Mo; Julie Gauthier; Jennifer Crosbie; Alistair T Pagnamenta; Jeffrey Munson; Annette M Estes; Andreas Fiebig; Andre Franke; Stefan Schreiber; Alexandre F R Stewart; Robert Roberts; Ruth McPherson; Stephen J Guter; Edwin H Cook; Geraldine Dawson; Gerard D Schellenberg; Agatino Battaglia; Elena Maestrini; Linda Jeng; Terry Hutchison; Evica Rajcan-Separovic; Albert E Chudley; Suzanne M E Lewis; Xudong Liu; Jeanette J Holden; Bridget Fernandez; Lonnie Zwaigenbaum; Susan E Bryson; Wendy Roberts; Peter Szatmari; Louise Gallagher; Michael R Stratton; Jozef Gecz; Angela F Brady; Charles E Schwartz; Russell J Schachar; Anthony P Monaco; Guy A Rouleau; Chi-Chung Hui; F Lucy Raymond; Stephen W Scherer; John B Vincent
Journal:  Sci Transl Med       Date:  2010-09-15       Impact factor: 17.956

9.  Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.

Authors:  Yanyan Liu; Yasong Du; Wenwen Liu; Caohua Yang; Yan Liu; Hongyan Wang; Xiaohong Gong
Journal:  PLoS One       Date:  2013-02-26       Impact factor: 3.240

10.  Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis.

Authors:  Eva Velthorst; Sean Froudist-Walsh; Eli Stahl; Douglas Ruderfer; Ilyan Ivanov; Joseph Buxbaum; Tobias Banaschewski; Arun L W Bokde; Uli Bromberg Dipl-Psych; Christian Büchel; Erin Burke Quinlan; Sylvane Desrivières; Herta Flor; Vincent Frouin; Hugh Garavan; Penny Gowland; Andreas Heinz; Bernd Ittermann; Marie-Laure Paillère Martinot; Eric Artiges; Frauke Nees; Dimitri Papadopoulos Orfanos; Tomáš Paus; Luise Poustka; Sarah Hohmann; Juliane H Fröhner; Michael N Smolka; Henrik Walter; Robert Whelan; Gunter Schumann; Abraham Reichenberg
Journal:  Transl Psychiatry       Date:  2018-09-26       Impact factor: 6.222
  10 in total

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