Literature DB >> 16259714

Prostaglandin F2alpha produced by inducible cyclooxygenase may contribute to the resolution of inflammation.

Paul R Colville-Nash1, Derek W Gilroy, Dean Willis, Mark J Paul-Clark, Adrian R Moore, Derek A Willoughby.   

Abstract

Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F2alpha concentrations rise during resolution of this model. These were reduced by the selective cyclooxygenase-2 inhibitor NS-398, which exacerbated inflammation. Concomitant treatment with NS-398 and the synthetic FP receptor agonist fluprostenol reversed this exacerbation. This suggests prostaglandin F2alpha produced by cyclooxygenase-2 contributes to resolution of this inflammatory reaction.

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Year:  2005        PMID： 16259714     DOI： 10.1163/156856005774382616

Source DB:  PubMed          Journal:  Inflammopharmacology        ISSN： 0925-4692            Impact factor:   4.473


  8 in total

1.  Inducible cyclooxygenase may have anti-inflammatory properties.

Authors:  D W Gilroy; P R Colville-Nash; D Willis; J Chivers; M J Paul-Clark; D A Willoughby
Journal:  Nat Med       Date:  1999-06       Impact factor: 53.440

2.  Pharmacological mediators of various immunological and non-immunological inflammatory reactions produced in the pleural cavity.

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Journal:  Agents Actions       Date:  1975-12

3.  Effects of prostaglandins PGF2a and PGE1 on vascular permeability.

Authors:  D A Willoughby
Journal:  J Pathol Bacteriol       Date:  1968-10

Review 4.  International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

Authors:  R A Coleman; W L Smith; S Narumiya
Journal:  Pharmacol Rev       Date:  1994-06       Impact factor: 25.468

5.  Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.

Authors:  J Shigeta; S Takahashi; S Okabe
Journal:  J Pharmacol Exp Ther       Date:  1998-09       Impact factor: 4.030

6.  Contractile response in isolated human groin lymphatics.

Authors:  T Sjöberg; P Alm; K E Andersson; L Norgren; S Steen
Journal:  Lymphology       Date:  1987-09       Impact factor: 1.286

7.  Vasoconstrictive effects of prostaglandin F2 alpha angiography on colonic lesions.

Authors:  Y Yuasa; E Kohda; K Ido; K Kodera; Y Narimatsu; Y Isobe; K Hiramatsu
Journal:  Radiology       Date:  1984-05       Impact factor: 11.105

8.  Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy.

Authors:  A Tomlinson; I Appleton; A R Moore; D W Gilroy; D Willis; J A Mitchell; D A Willoughby
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739
  8 in total
  4 in total

1.  Professor Derek Albert Willoughby (1930-2004).

Authors:  K D Rainsford
Journal:  Inflammopharmacology       Date:  2005       Impact factor: 4.473

2.  Resolvin D1 Improves the Resolution of Inflammation via Activating NF-κB p50/p50-Mediated Cyclooxygenase-2 Expression in Acute Respiratory Distress Syndrome.

Authors:  Ye Gao; Huawei Zhang; Lingchun Luo; Jing Lin; Dan Li; Sisi Zheng; Hua Huang; Songfan Yan; Jingxiang Yang; Yu Hao; Hui Li; Fang Gao Smith; Shengwei Jin
Journal:  J Immunol       Date:  2017-08-09       Impact factor: 5.422

3.  Protectin DX promotes the inflammatory resolution via activating COX-2/L-PGDS-PGD2 and DP1 receptor in acute respiratory distress syndrome.

Authors:  Xin Hu; Ye-An Zhang; Ben Chen; Zi Jin; Mei-Lin Lin; Ming Li; Hong-Xia Mei; Jia-Chao Lu; Yu-Qiang Gong; Sheng-Wei Jin; Sheng-Xing Zheng
Journal:  Int Immunopharmacol       Date:  2021-11-10       Impact factor: 4.932

Review 4.  Prostanoids and Resolution of Inflammation - Beyond the Lipid-Mediator Class Switch.

Authors:  Tobias Schmid; Bernhard Brüne
Journal:  Front Immunol       Date:  2021-07-12       Impact factor: 7.561
  4 in total

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