Literature DB >> 16257558

The rationale behind a vaccine based on multiple HIV antigens.

E Rollman1, A Bråve, A Boberg, L Gudmundsdotter, G Engström, M Isaguliants, K Ljungberg, B Lundgren, P Blomberg, J Hinkula, B Hejdeman, E Sandström, M Liu, B Wahren.   

Abstract

The viral diversity of HIV-1 is likely to require a vaccine strategy that induces broad cellular and humoral anti-HIV-1 immunity. Our strategy is based on multiple HIV-1 DNA immunogens together with adjuvant recombinant granulocyte-macrophage stimulating factor. This article describes pre-clinical and clinical work preceding the initiation of clinical HIV-1 phase I/II trials.

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Year:  2005        PMID: 16257558     DOI: 10.1016/j.micinf.2005.07.017

Source DB:  PubMed          Journal:  Microbes Infect        ISSN: 1286-4579            Impact factor:   2.700


  12 in total

Review 1.  Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications.

Authors:  L Buonaguro; M L Tornesello; F M Buonaguro
Journal:  J Virol       Date:  2007-07-18       Impact factor: 5.103

Review 2.  New developments in an old strategy: heterologous vector primes and envelope protein boosts in HIV vaccine design.

Authors:  Thomas Musich; Marjorie Robert-Guroff
Journal:  Expert Rev Vaccines       Date:  2016-03-16       Impact factor: 5.217

3.  Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials.

Authors:  Scott A Brown; Sherri L Surman; Robert Sealy; Bart G Jones; Karen S Slobod; Kristen Branum; Timothy D Lockey; Nanna Howlett; Pamela Freiden; Patricia Flynn; Julia L Hurwitz
Journal:  Viruses       Date:  2010-02-01       Impact factor: 5.048

4.  Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity.

Authors:  Lindvi Gudmundsdotter; Charlotta Nilsson; Andreas Brave; Bo Hejdeman; Patricia Earl; Bernard Moss; Merlin Robb; Josephine Cox; Nelson Michael; Mary Marovich; Gunnel Biberfeld; Eric Sandström; Britta Wahren
Journal:  Vaccine       Date:  2009-05-29       Impact factor: 3.641

Review 5.  Preclinical and clinical development of a multi-envelope, DNA-virus-protein (D-V-P) HIV-1 vaccine.

Authors:  Robert Sealy; Karen S Slobod; Patricia Flynn; Kristen Branum; Sherri Surman; Bart Jones; Pamela Freiden; Timothy Lockey; Nanna Howlett; Julia L Hurwitz
Journal:  Int Rev Immunol       Date:  2009       Impact factor: 5.311

6.  Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: a phase I randomised Trial in HIV-uninfected Indian volunteers.

Authors:  Sanjay Mehendale; Madhuri Thakar; Seema Sahay; Makesh Kumar; Ashwini Shete; Pattabiraman Sathyamurthi; Amita Verma; Swarali Kurle; Aparna Shrotri; Jill Gilmour; Rajat Goyal; Len Dally; Eddy Sayeed; Devika Zachariah; James Ackland; Sonali Kochhar; Josephine H Cox; Jean-Louis Excler; Vasanthapuram Kumaraswami; Ramesh Paranjape; Vadakkuppatu Devasenapathi Ramanathan
Journal:  PLoS One       Date:  2013-02-13       Impact factor: 3.240

Review 7.  Therapeutic immunization for HIV.

Authors:  Lindvi Gudmundsdotter; Anna Sjödin; Ann-Charlotte Boström; Bo Hejdeman; Rebecca Theve-Palm; Annette Alaeus; Knut Lidman; Britta Wahren
Journal:  Springer Semin Immunopathol       Date:  2006-10-10

8.  Frequent associations between CTL and T-Helper epitopes in HIV-1 genomes and implications for multi-epitope vaccine designs.

Authors:  Sinu Paul; Helen Piontkivska
Journal:  BMC Microbiol       Date:  2010-08-09       Impact factor: 3.605

9.  Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice.

Authors:  Anastasia Latanova; Stefan Petkov; Yulia Kuzmenko; Athina Kilpeläinen; Alexander Ivanov; Olga Smirnova; Olga Krotova; Sergey Korolev; Jorma Hinkula; Vadim Karpov; Maria Isaguliants; Elizaveta Starodubova
Journal:  J Immunol Res       Date:  2017-06-22       Impact factor: 4.818

10.  Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques.

Authors:  Marie Borggren; Lasse Vinner; Betina Skovgaard Andresen; Berit Grevstad; Johanna Repits; Mark Melchers; Tara Laura Elvang; Rogier W Sanders; Frédéric Martinon; Nathalie Dereuddre-Bosquet; Emma Joanne Bowles; Guillaume Stewart-Jones; Priscilla Biswas; Gabriella Scarlatti; Marianne Jansson; Leo Heyndrickx; Roger Le Grand; Anders Fomsgaard
Journal:  Vaccines (Basel)       Date:  2013-07-19
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